SVBP (small vasohibin binding protein)

2015-06-01  

Identity

HGNC
SVBP
LOCATION
1p34.2
LOCUSID
374969
ALIAS
CCDC23,NEDAHM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 374969
MIM: 617853
HGNC: 29204
Ensembl: ENSG00000177868

Variants:

dbSNP: 374969
ClinVar: 374969
TCGA: ENSG00000177868
COSMIC: SVBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177868ENST00000372521Q8N300
ENSG00000177868ENST00000372522Q8N300

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
306070232019Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia.10
311718302019Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.31
312359112019Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.21
312704702019Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.12
306070232019Loss of function of SVBP leads to autosomal recessive intellectual disability, microcephaly, ataxia, and hypotonia.10
311718302019Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.31
312359112019Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.21
312704702019Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.12
278790172017Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release.6
278790172017Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release.6
226140112013Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma.43
226140112013Vasohibin 2 is transcriptionally activated and promotes angiogenesis in hepatocellular carcinoma.43
207363122010Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion.26
207363122010Isolation of a small vasohibin-binding protein (SVBP) and its role in vasohibin secretion.26

Citation

Dessen P

SVBP (small vasohibin binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55250/svbp-(small-vasohibin-binding-protein)