Identity
HGNC
LOCATION
12q21.2
LOCUSID
ALIAS
MST120,MSTP120,ORP8,OSBP10
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 114882
MIM: 606736
HGNC: 16396
Ensembl: ENSG00000091039
Variants:
dbSNP: 114882
ClinVar: 114882
TCGA: ENSG00000091039
COSMIC: OSBPL8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32323800 | 2020 | ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer. | 6 |
| 32323800 | 2020 | ORP8 induces apoptosis by releasing cytochrome c from mitochondria in non‑small cell lung cancer. | 6 |
| 29409900 | 2018 | Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites. | 6 |
| 29472386 | 2018 | PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites. | 93 |
| 29748134 | 2018 | Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments. | 17 |
| 29409900 | 2018 | Both the PH domain and N-terminal region of oxysterol-binding protein related protein 8S are required for localization to PM-ER contact sites. | 6 |
| 29472386 | 2018 | PI(4,5)P(2) controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites. | 93 |
| 29748134 | 2018 | Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments. | 17 |
| 27983927 | 2017 | Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis. | 18 |
| 28970484 | 2017 | ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P (2)) and regulate its level at the plasma membrane. | 85 |
| 27983927 | 2017 | Oxysterol-Binding Protein-Related Protein 8 Inhibits Gastric Cancer Growth Through Induction of ER Stress, Inhibition of Wnt Signaling, and Activation of Apoptosis. | 18 |
| 28970484 | 2017 | ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P (2)) and regulate its level at the plasma membrane. | 85 |
| 27113756 | 2016 | ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function. | 122 |
| 27530118 | 2016 | Oxysterol binding protein-related protein 8 mediates the cytotoxicity of 25-hydroxycholesterol. | 14 |
| 27113756 | 2016 | ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function. | 122 |
Citation
Dessen P
OSBPL8 (oxysterol binding protein like 8)
Atlas Genet Cytogenet Oncol Haematol. 2015-06-01
Online version: http://atlasgeneticsoncology.org/gene/55260/osbpl8-(oxysterol-binding-protein-like-8)
