Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55270
MIM: 615792
HGNC: 23063
Ensembl: ENSG00000136159
Variants:
dbSNP: 55270
ClinVar: 55270
TCGA: ENSG00000136159
COSMIC: NUDT15
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136159 | ENST00000258662 | Q9NV35 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Metabolism of nucleotides | REACTOME | R-HSA-15869 |
| Phosphate bond hydrolysis by NUDT proteins | REACTOME | R-HSA-2393930 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165817398 | Myelosuppression | Disease | VariantAnnotation | associated | PD | ||
| PA165819269 | TPMT*2 | Haplotype | LabelAnnotation | associated | |||
| PA165819270 | TPMT*3A | Haplotype | LabelAnnotation | associated | |||
| PA165819272 | TPMT*3C | Haplotype | LabelAnnotation | associated | |||
| PA166153171 | 8-oxo-dgtp | Chemical | MultilinkAnnotation | not associated | 26238318 | ||
| PA166154759 | rs116855232 | Variant | LabelAnnotation, VipGene | associated | 26076924, 26503813, 26590936, 26735160, 26033531 | ||
| PA166160633 | thioguanosine triphosphate | Chemical | VariantAnnotation | not associated | PK | 27530327 | |
| PA166160634 | deoxy-thioguanosine triphosphate | Chemical | VariantAnnotation | not associated | PK | 27530327 | |
| PA444773 | Leukopenia | Disease | VariantAnnotation | associated | PD | 26735160, 28146264, 29923122, 30048756 | |
| PA445221 | Pancytopenia | Disease | ClinicalAnnotation | associated | PD | 30035323, 30101994 | |
| PA445846 | Thrombocytopenia | Disease | ClinicalAnnotation | associated | PD | 30035323, 30101994 | |
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 26033531, 26076924, 26503813, 26590936, 26735160, 27095468, 27193222, 27381176, 27416873, 27530327, 27558924, 27577869, 27604507, 28146264, 29923122, 30048756 |
| PA446155 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | Disease | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 26033531, 26076924, 26503813, 26590936, 26735160, 26878724, 27095468, 27193222, 27381176, 27416873, 27530327, 27558924, 27577869, 27604507, 28146264, 28445187, 28659275, 29923122, 29967377, 30048756 |
| PA448515 | azathioprine | Chemical | ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, Literature, MultilinkAnnotation, VariantAnnotation, VipGene | associated | PK | PD | 25108385, 26033531, 26076924, 26503813, 26590936, 26735160, 27095468, 27193222, 27381176, 27416873, 27530327, 27558924, 27577869, 27604507, 28146264, 29923122, 30035323, 30048756, 30101994 |
| PA450379 | mercaptopurine | Chemical | ClinicalAnnotation, GuidelineAnnotation, LabelAnnotation, VariantAnnotation, VipGene | associated | PK | PD | 26033531, 26076924, 26503813, 26590936, 26735160, 26878724, 27095468, 27193222, 27381176, 27416873, 27530327, 27558924, 27577869, 27604507, 28146264, 28445187, 28659275, 29923122, 29967377, 30035323, 30048756, 30101994 |
| PA451663 | thioguanine | Chemical | GuidelineAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation | associated | PD | 27530327 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37794799 | 2024 | Association of NUDT15 gene polymorphism with adverse reaction, treatment efficacy, and dose of 6-mercaptopurine in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis. | 0 |
| 38682355 | 2024 | Novel variant in Nudix hydrolase 15 gene influences 6-mercaptopurine toxicity in childhood acute lymphoblastic leukemia patients. | 0 |
| 38936894 | 2024 | NUDT15 Polymorphism and Its Association With Mercaptopurine Hematotoxicity in Acute Lymphoblastic Leukemia in Indonesian Children. | 0 |
| 37794799 | 2024 | Association of NUDT15 gene polymorphism with adverse reaction, treatment efficacy, and dose of 6-mercaptopurine in patients with acute lymphoblastic leukemia: a systematic review and meta-analysis. | 0 |
| 38682355 | 2024 | Novel variant in Nudix hydrolase 15 gene influences 6-mercaptopurine toxicity in childhood acute lymphoblastic leukemia patients. | 0 |
| 38936894 | 2024 | NUDT15 Polymorphism and Its Association With Mercaptopurine Hematotoxicity in Acute Lymphoblastic Leukemia in Indonesian Children. | 0 |
| 36858569 | 2023 | Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia. | 0 |
| 36873097 | 2023 | The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia. | 0 |
| 37454061 | 2023 | Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease. | 0 |
| 37556121 | 2023 | The c.415C>T polymorphism in NUDT15 is more frequent than the polymorphisms in TPMT in Chilean patients who use thiopurine drugs. | 1 |
| 36858569 | 2023 | Single-Nucleotide Polymorphisms, c.415C > T (Arg139Cys) and c.416G > A (Arg139His), in the NUDT15 Gene Are Associated with Thiopurine-Induced Leukopenia. | 0 |
| 36873097 | 2023 | The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia. | 0 |
| 37454061 | 2023 | Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease. | 0 |
| 37556121 | 2023 | The c.415C>T polymorphism in NUDT15 is more frequent than the polymorphisms in TPMT in Chilean patients who use thiopurine drugs. | 1 |
| 34582038 | 2022 | TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results. | 11 |
Citation
Dessen P
NUDT15 (nudix hydrolase 15)
Atlas Genet Cytogenet Oncol Haematol. 2015-06-01
Online version: http://atlasgeneticsoncology.org/gene/55280/nudt15-(nudix-hydrolase-15)
