VDAC2 (voltage dependent anion channel 2)

2015-06-01  

Identity

HGNC
LOCATION
10q22.2
LOCUSID
ALIAS
POR

Other Information

Locus ID:

NCBI: 7417
MIM: 193245
HGNC: 12672
Ensembl: ENSG00000165637

Variants:

dbSNP: 7417
ClinVar: 7417
TCGA: ENSG00000165637
COSMIC: VDAC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165637ENST00000298468A0A0A0MR02
ENSG00000165637ENST00000313132P45880
ENSG00000165637ENST00000332211P45880
ENSG00000165637ENST00000332211A0A024QZT0
ENSG00000165637ENST00000344036Q5JSD2
ENSG00000165637ENST00000413289A2A3S1
ENSG00000165637ENST00000447677Q5JSD1
ENSG00000165637ENST00000543351P45880
ENSG00000165637ENST00000543351A0A024QZT0

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Huntington's diseaseKEGGko05016
Calcium signaling pathwayKEGGhsa04020
Parkinson's diseaseKEGGhsa05012
Huntington's diseaseKEGGhsa05016
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364450632023STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.11
364450632023STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.11
333865012021Protein mass spectrometry reveals lycorine exerting anti-multiple-myeloma effect by acting on VDAC2 and causing mitochondrial abnormalities.0
333865012021Protein mass spectrometry reveals lycorine exerting anti-multiple-myeloma effect by acting on VDAC2 and causing mitochondrial abnormalities.0
319743802020Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.165
319819672020Structure-based modeling of turnover of Bcl-2 family proteins bound to voltage-dependent anion channel 2 (VDAC2): Implications for the mechanisms of proapoptotic activation of Bak and Bax in vivo.4
320981322020A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs).13
326419862020Inflammatory IFIT3 renders chemotherapy resistance by regulating post-translational modification of VDAC2 in pancreatic cancer.21
328296732020Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance.9
330467832020Bisindolylpyrrole triggers transient mitochondrial permeability transitions to cause apoptosis in a VDAC1/2 and cyclophilin D-dependent manner via the ANT-associated pore.2
330672552020Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites.21
330674182020BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.5
319743802020Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.165
319819672020Structure-based modeling of turnover of Bcl-2 family proteins bound to voltage-dependent anion channel 2 (VDAC2): Implications for the mechanisms of proapoptotic activation of Bak and Bax in vivo.4
320981322020A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs).13

Citation

Dessen P

VDAC2 (voltage dependent anion channel 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/55282/vdac2-(voltage-dependent-anion-channel-2)