NAT10 (N-acetyltransferase 10)

2015-08-01  

Identity

HGNC
LOCATION
11p13
LOCUSID
ALIAS
ALP,Kre33,NET43
FUSION GENES

Other Information

Locus ID:

NCBI: 55226
MIM: 609221
HGNC: 29830
Ensembl: ENSG00000135372

Variants:

dbSNP: 55226
ClinVar: 55226
TCGA: ENSG00000135372
COSMIC: NAT10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135372ENST00000257829Q9H0A0
ENSG00000135372ENST00000527971E9PMU0
ENSG00000135372ENST00000529523E9PJN6
ENSG00000135372ENST00000531159Q9H0A0
ENSG00000135372ENST00000615292A0A087WV29

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
rRNA modification in the nucleus and cytosolREACTOMER-HSA-6790901
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381674912024Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance.0
381692842024N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA.0
381825712024CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.0
382151942024N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling.3
382469182024RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac(4)C modification.1
384095502024Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.0
384099182024NAT10-mediated mRNA N4-acetylcytidine modification of MDR1 and BCRP promotes breast cancer progression.1
384590192024N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.0
389615192024N-acetyltransferase 10 facilitates tumorigenesis of diffuse large B-cell lymphoma by regulating AMPK/mTOR signalling through N4-acetylcytidine modification of SLC30A9.1
381674912024Decreased expression of NAT10 in peripheral blood mononuclear cells from new-onset ankylosing spondylitis and its clinical significance.0
381692842024N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modification of the lymphocyte antigen six family member E (LY6E) mRNA.0
381825712024CLIC3 interacts with NAT10 to inhibit N4-acetylcytidine modification of p21 mRNA and promote bladder cancer progression.0
382151942024N-acetyltransferase NAT10 controls cell fates via connecting mRNA cytidine acetylation to chromatin signaling.3
382469182024RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac(4)C modification.1
384095502024Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10.0

Citation

Dessen P

NAT10 (N-acetyltransferase 10)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55305/