CHTOP (chromatin target of PRMT1)

2015-08-01  

Identity

HGNC
CHTOP
LOCATION
1q21.3
LOCUSID
26097
ALIAS
C10orf77,C1orf77,FL-SRAG,FOP,SRAG,SRAG-3,SRAG-5,pp7704
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26097
MIM: 614206
HGNC: 24511
Ensembl: ENSG00000160679

Variants:

dbSNP: 26097
ClinVar: 26097
TCGA: ENSG00000160679
COSMIC: CHTOP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160679ENST00000368686Q5T7Y7
ENSG00000160679ENST00000368687X6R700
ENSG00000160679ENST00000368690Q9Y3Y2
ENSG00000160679ENST00000368694Q9Y3Y2
ENSG00000160679ENST00000403433Q9Y3Y2
ENSG00000160679ENST00000614256A0A087X1B7

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349849762022Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation.14
349849762022Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation.14
327366532020Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.14
327366532020Circulating unmethylated CHTOP and INS DNA fragments provide evidence of possible islet cell death in youth with obesity and diabetes.14
309108502019Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer.5
309108502019Chromatin target of protein arginine methyltransferase regulates invasion, chemoresistance, and stemness in epithelial ovarian cancer.5
276832232016Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA.10
276832232016Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA.10
2528478920145-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.72
2528478920145-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.72
232999392013Chtop is a component of the dynamic TREX mRNA export complex.55
238263322013Mapping interactions between mRNA export factors in living cells.9
232999392013Chtop is a component of the dynamic TREX mRNA export complex.55
238263322013Mapping interactions between mRNA export factors in living cells.9
198582912010Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.29

Citation

Dessen P

CHTOP (chromatin target of PRMT1)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55309/chtop-(chromatin-target-of-prmt1)