RAET1L (retinoic acid early transcript 1L)

2015-08-01  

Identity

HGNC
LOCATION
6q25.1
LOCUSID
ALIAS
ULBP6

Other Information

Locus ID:

NCBI: 154064
MIM: 611047
HGNC: 16798
Ensembl: ENSG00000155918

Variants:

dbSNP: 154064
ClinVar: 154064
TCGA: ENSG00000155918
COSMIC: RAET1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155918ENST00000286380Q5VY80
ENSG00000155918ENST00000367341Q5VY80

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

References

Pubmed IDYearTitleCitations
313024572019From genomic variation to protein aberration: Mutational analysis of single nucleotide polymorphism present in ULBP6 gene and implication in immune response.0
313024572019From genomic variation to protein aberration: Mutational analysis of single nucleotide polymorphism present in ULBP6 gene and implication in immune response.0
285594512017A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.16
285594512017A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.16
252126042014Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.30
252126042014Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells.30
230255442012The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly influences the clinical outcome of allogeneic stem cell transplantation.13
230255442012The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly influences the clinical outcome of allogeneic stem cell transplantation.13
202196102010Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.10
202196102010Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.10
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
202196102010Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.10
202196102010Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.10
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
196580972009ULBP6/RAET1L is an additional human NKG2D ligand.56

Citation

Dessen P

RAET1L (retinoic acid early transcript 1L)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55312/raet1l-(retinoic-acid-early-transcript-1l)