PI4KB (phosphatidylinositol 4-kinase beta)

2015-08-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
NPIK,PI4K-BETA,PI4K92,PI4KBETA,PI4KIII,PI4KIIIBETA,PIK4CB
FUSION GENES

Other Information

Locus ID:

NCBI: 5298
MIM: 602758
HGNC: 8984
Ensembl: ENSG00000143393

Variants:

dbSNP: 5298
ClinVar: 5298
TCGA: ENSG00000143393
COSMIC: PI4KB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143393ENST00000368873Q9UBF8
ENSG00000143393ENST00000368875A0A0B4J1S8
ENSG00000143393ENST00000430800F8W860
ENSG00000143393ENST00000438243A0A0A0MSL0
ENSG00000143393ENST00000446339H0Y4F8
ENSG00000143393ENST00000455060A6PVV8
ENSG00000143393ENST00000489223E9PL47
ENSG00000143393ENST00000489889H0YCW3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGhsa_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4KEGGM00130
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381342182024Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins.0
381892492024N-terminal acetyltransferase 6 facilitates enterovirus 71 replication by regulating PI4KB expression and replication organelle biogenesis.0
381342182024Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins.0
381892492024N-terminal acetyltransferase 6 facilitates enterovirus 71 replication by regulating PI4KB expression and replication organelle biogenesis.0
371956332023The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi.4
376161632023Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.2
371956332023The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi.4
376161632023Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in gastrointestinal stromal tumor cells.2
330902892021Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes.2
342582972021circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis.6
330902892021Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes.2
342582972021circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis.6
325837402020Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number.1
333587772020Phosphatidylinositol 4-kinase β mutations cause nonsyndromic sensorineural deafness and inner ear malformation.1
325837402020Phosphatidylinositol 4-kinase III beta regulates cell shape, migration, and focal adhesion number.1

Citation

Dessen P

PI4KB (phosphatidylinositol 4-kinase beta)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55325/js/lib/gene-explorer/humanGenome