Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1812
MIM: 126449
HGNC: 3020
Ensembl: ENSG00000184845
Variants:
dbSNP: 1812
ClinVar: 1812
TCGA: ENSG00000184845
COSMIC: DRD1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000184845 | ENST00000393752 | P21728 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131548935 | drotrecogin alfa | Chemical | VariantAnnotation | associated | PD | 22310353 | |
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation | associated | PD | 18092181 | |
| PA446771 | Sepsis | Disease | VariantAnnotation | associated | PD | 22310353 | |
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | ClinicalAnnotation | associated | PD | 23952191 | |
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | 21047205 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 17092969 | |
| PA448687 | bupropion | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449061 | clozapine | Chemical | ClinicalAnnotation | associated | PD | 17092969 | |
| PA449269 | dextroamphetamine | Chemical | ClinicalAnnotation | associated | PD | 23952191 | |
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD | 21047205 | |
| PA450464 | methylphenidate | Chemical | ClinicalAnnotation | associated | PD | 23952191 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PD | 18092181 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38302439 | 2024 | Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture. | 2 |
| 38572507 | 2024 | DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC. | 0 |
| 38302439 | 2024 | Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture. | 2 |
| 38572507 | 2024 | DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC. | 0 |
| 36441110 | 2023 | Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling. | 5 |
| 36649260 | 2023 | Unravelling neurotransmitters impairment in primary progressive aphasias. | 3 |
| 36894051 | 2023 | Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway. | 1 |
| 37024146 | 2023 | Dopamine Receptor D1 Is Exempt from Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts. | 1 |
| 37252844 | 2023 | DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons. | 4 |
| 36441110 | 2023 | Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling. | 5 |
| 36649260 | 2023 | Unravelling neurotransmitters impairment in primary progressive aphasias. | 3 |
| 36894051 | 2023 | Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway. | 1 |
| 37024146 | 2023 | Dopamine Receptor D1 Is Exempt from Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung Fibroblasts. | 1 |
| 37252844 | 2023 | DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons. | 4 |
| 34870351 | 2022 | An Investigation into the Association Between Dopamine Receptor D1 Multilocus Genetic Variation, Multiparametric Magnetic Resonance Imaging, and Antidepressant Treatment. | 0 |
Citation
Dessen P
DRD1 (dopamine receptor D1)
Atlas Genet Cytogenet Oncol Haematol. 2015-08-01
Online version: http://atlasgeneticsoncology.org/gene/55334/drd1-(dopamine-receptor-d1)
