Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1491
MIM: 607657
HGNC: 2501
Ensembl: ENSG00000116761
Variants:
dbSNP: 1491
ClinVar: 1491
TCGA: ENSG00000116761
COSMIC: CTH
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000116761 | ENST00000346806 | P32929 |
| ENSG00000116761 | ENST00000370938 | P32929 |
| ENSG00000116761 | ENST00000411986 | P32929 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166122646 | hemopoietic stem cell transplant | Disease | ClinicalAnnotation | associated | PD | 27779248 | |
| PA448691 | busulfan | Chemical | ClinicalAnnotation | associated | PD | 27779248 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | 27779248 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38388661 | 2024 | Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding. | 0 |
| 38388661 | 2024 | Identifying CTH and MAP1LC3B as ferroptosis biomarkers for prognostic indication in gastric cancer decoding. | 0 |
| 37300955 | 2023 | Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation. | 3 |
| 37800327 | 2023 | Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence. | 1 |
| 37922764 | 2023 | Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation. | 1 |
| 38238950 | 2023 | [Exploration of cystathionine β-synthase and cystathionine γ-lyase gene expression poor prognostic predictive value with the application of bioinformatics data mining in liver cancer]. | 0 |
| 37300955 | 2023 | Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation. | 3 |
| 37800327 | 2023 | Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial Senescence. | 1 |
| 37922764 | 2023 | Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation. | 1 |
| 38238950 | 2023 | [Exploration of cystathionine β-synthase and cystathionine γ-lyase gene expression poor prognostic predictive value with the application of bioinformatics data mining in liver cancer]. | 0 |
| 36310322 | 2022 | Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma. | 0 |
| 36514219 | 2022 | KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H (2)S axis and contributes to pancreatic cancer growth. | 3 |
| 36310322 | 2022 | Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma. | 0 |
| 36514219 | 2022 | KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H (2)S axis and contributes to pancreatic cancer growth. | 3 |
| 33760156 | 2021 | Hydrogen sulfide improves ox‑LDL‑induced expression levels of Lp‑PLA(2) in THP‑1 monocytes via the p38MAPK pathway. | 4 |
Citation
Dessen P
CTH (cystathionine gamma-lyase)
Atlas Genet Cytogenet Oncol Haematol. 2015-08-01
Online version: http://atlasgeneticsoncology.org/gene/55338/cth-(cystathionine-gamma-lyase)
