CTH (cystathionine gamma-lyase)

2015-08-01  

Identity

HGNC
LOCATION
1p31.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1491
MIM: 607657
HGNC: 2501
Ensembl: ENSG00000116761

Variants:

dbSNP: 1491
ClinVar: 1491
TCGA: ENSG00000116761
COSMIC: CTH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116761ENST00000346806P32929
ENSG00000116761ENST00000370938P32929
ENSG00000116761ENST00000411986P32929

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Selenocompound metabolismKEGGko00450
Glycine, serine and threonine metabolismKEGGhsa00260
Selenocompound metabolismKEGGhsa00450
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Cysteine biosynthesis, homocysteine + serine => cysteineKEGGhsa_M00338
Cysteine biosynthesis, homocysteine + serine => cysteineKEGGM00338
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Cysteine formation from homocysteineREACTOMER-HSA-1614603
Degradation of cysteine and homocysteineREACTOMER-HSA-1614558
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2SeREACTOMER-HSA-2408508

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166122646hemopoietic stem cell transplantDiseaseClinicalAnnotationassociatedPD27779248
PA448691busulfanChemicalClinicalAnnotationassociatedPD27779248
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD27779248

References

Pubmed IDYearTitleCitations
195314792009Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.165
192616092009H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia.130
233930102013H₂S protects against pressure overload-induced heart failure via upregulation of endothelial nitric oxide synthase.108
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
190198292009Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S.43
153476702004Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1.40
252033952015miRNA-30 family inhibition protects against cardiac ischemic injury by regulating cystathionine-γ-lyase expression.34
223608592012Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines.33
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30

Citation

Dessen P

CTH (cystathionine gamma-lyase)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55338/cth-(cystathionine-gamma-lyase)