CNOT1 (CCR4-NOT transcription complex subunit 1)

2015-08-01  

Identity

HGNC
LOCATION
16q21
LOCUSID
ALIAS
AD-005,CDC39,HPE12,NOT1,NOT1H,VIBOS
FUSION GENES

Other Information

Locus ID:

NCBI: 23019
MIM: 604917
HGNC: 7877
Ensembl: ENSG00000125107

Variants:

dbSNP: 23019
ClinVar: 23019
TCGA: ENSG00000125107
COSMIC: CNOT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125107ENST00000317147A5YKK6
ENSG00000125107ENST00000441024A5YKK6
ENSG00000125107ENST00000562046H3BR89
ENSG00000125107ENST00000564557H3BT18
ENSG00000125107ENST00000565605H3BU44
ENSG00000125107ENST00000565697H3BPF1
ENSG00000125107ENST00000566240H3BTH2
ENSG00000125107ENST00000567133H3BNB1
ENSG00000125107ENST00000567188A5YKK6
ENSG00000125107ENST00000567285H3BVC9
ENSG00000125107ENST00000568917H3BMZ2
ENSG00000125107ENST00000569020H3BPF1
ENSG00000125107ENST00000569240A5YKK6
ENSG00000125107ENST00000569882H3BMH0
ENSG00000125107ENST00000628857H3BU44

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
275588972016YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.156
247685382014Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.106
247685402014A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.105
236445992013Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.89
195583672009Human Ccr4-Not complexes contain variable deadenylase subunits.73
117339892001Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.59
250352962014Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1.49
229771752012The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex.42
241212322013Structure and assembly of the NOT module of the human CCR4-NOT complex.40
167787662006Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.38

Citation

Dessen P

CNOT1 (CCR4-NOT transcription complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55343/cnot1-(ccr4-not-transcription-complex-subunit-1)