HACD3 (3-hydroxyacyl-CoA dehydratase 3)

2015-08-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
B-IND1,BIND1,HSPC121,PTPLAD1
FUSION GENES

Other Information

Locus ID:

NCBI: 51495
MIM: 615940
HGNC: 24175
Ensembl: ENSG00000074696

Variants:

dbSNP: 51495
ClinVar: 51495
TCGA: ENSG00000074696
COSMIC: HACD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074696ENST00000261875Q9P035
ENSG00000074696ENST00000442729Q9P035
ENSG00000074696ENST00000562832H3BMZ1
ENSG00000074696ENST00000562901H3BRL8
ENSG00000074696ENST00000565299H3BS72
ENSG00000074696ENST00000566074H3BRL8
ENSG00000074696ENST00000566511H3BRL8
ENSG00000074696ENST00000568793H3BPZ1
ENSG00000074696ENST00000569894H3BRL8

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Fatty acid elongationKEGGko00062
Biosynthesis of unsaturated fatty acidsKEGGko01040
Fatty acid elongationKEGGhsa00062
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
Fatty acid biosynthesis, elongation, endoplasmic reticulumKEGGhsa_M00415
Fatty acid biosynthesis, elongation, endoplasmic reticulumKEGGM00415
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386175302024PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.0
386175302024PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.0
303003852018A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.6
303003852018A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes.6
256875712015The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.14
256875712015The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.14
225605252012Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.24
225605252012Genetic Loci implicated in erythroid differentiation and cell cycle regulation are associated with red blood cell traits.24
196568722009Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway.20
196568722009Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway.20
181604382008Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication.29
181604382008Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication.29
165164062006Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors.2
165164062006Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors.2

Citation

Dessen P

HACD3 (3-hydroxyacyl-CoA dehydratase 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55355/hacd3-(3-hydroxyacyl-coa-dehydratase-3)