Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3158
MIM: 600234
HGNC: 5008
Ensembl: ENSG00000134240
Variants:
dbSNP: 3158
ClinVar: 3158
TCGA: ENSG00000134240
COSMIC: HMGCS2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000134240 | ENST00000369406 | P54868 |
| ENSG00000134240 | ENST00000369406 | A0A140VJL2 |
| ENSG00000134240 | ENST00000544913 | P54868 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444522 | Hyperglycemia | Disease | ClinicalAnnotation | associated | PD | 29523524 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 29523524 | |
| PA448953 | chlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 29523524 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 29523524 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38658970 | 2024 | Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts. | 0 |
| 38704133 | 2024 | BET inhibition decreases HMGCS2 and sensitizes resistant pancreatic tumors to gemcitabine. | 0 |
| 38658970 | 2024 | Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts. | 0 |
| 38704133 | 2024 | BET inhibition decreases HMGCS2 and sensitizes resistant pancreatic tumors to gemcitabine. | 0 |
| 36629048 | 2023 | LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease. | 6 |
| 37670031 | 2023 | HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth. | 1 |
| 36629048 | 2023 | LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease. | 6 |
| 37670031 | 2023 | HMGCS2 serves as a potential biomarker for inhibition of renal clear cell carcinoma growth. | 1 |
| 35421611 | 2022 | Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis. | 23 |
| 35421611 | 2022 | Hmgcs2-mediated ketogenesis modulates high-fat diet-induced hepatosteatosis. | 23 |
| 34238920 | 2021 | Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation. | 10 |
| 34260294 | 2021 | HMGCS2 in metabolic pathways was associated with overall survival in hepatocellular carcinoma: A LASSO-derived study. | 6 |
| 34274945 | 2021 | SLC38A4 functions as a tumour suppressor in hepatocellular carcinoma through modulating Wnt/β-catenin/MYC/HMGCS2 axis. | 27 |
| 34624592 | 2021 | Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma. | 4 |
| 34944058 | 2021 | PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α. | 4 |
Citation
Dessen P
HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2)
Atlas Genet Cytogenet Oncol Haematol. 2015-08-01
Online version: http://atlasgeneticsoncology.org/gene/55366/hmgcs2-(3-hydroxy-3-methylglutaryl-coa-synthase-2)
