Identity
HGNC
LOCATION
20p13
LOCUSID
ALIAS
ADRA1,ADRA1A,ADRA1R,ALPHA1,DAR,dJ779E11.2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 146
MIM: 104219
HGNC: 280
Ensembl: ENSG00000171873
Variants:
dbSNP: 146
ClinVar: 146
TCGA: ENSG00000171873
COSMIC: ADRA1D
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000171873 | ENST00000379453 | P25100 |
| ENSG00000171873 | ENST00000379453 | B0ZBE0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712344 | Alpha-adrenoreceptor antagonists | Chemical | Pathway | associated | |||
| PA449396 | dopamine | Chemical | Pathway | associated | |||
| PA449470 | epinephrine | Chemical | Pathway | associated | |||
| PA450121 | isoproterenol | Chemical | Pathway | associated | |||
| PA450431 | methoxamine | Chemical | Pathway | associated | |||
| PA450649 | norepinephrine | Chemical | Pathway | associated | |||
| PA450935 | phenylephrine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37571902 | 2023 | Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis. | 1 |
| 37571902 | 2023 | Functional Involvement of ADRA1D in Cutaneous Melanoma Progression and Angiogenesis. | 1 |
| 32085899 | 2020 | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | 9 |
| 32350295 | 2020 | N-glycosylation of α(1D)-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis. | 5 |
| 32085899 | 2020 | Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α(1)-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays. | 9 |
| 32350295 | 2020 | N-glycosylation of α(1D)-adrenergic receptor N-terminal domain is required for correct trafficking, function, and biogenesis. | 5 |
| 30419287 | 2019 | Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α(1D)-adrenergic receptor subcellular localization and signaling. | 3 |
| 30419287 | 2019 | Distinct phosphorylation sites/clusters in the carboxyl terminus regulate α(1D)-adrenergic receptor subcellular localization and signaling. | 3 |
| 29089212 | 2018 | Up-regulation of α(1)-adrenoceptors in burn and keloid scars. | 7 |
| 29089212 | 2018 | Up-regulation of α(1)-adrenoceptors in burn and keloid scars. | 7 |
| 28862946 | 2017 | α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells. | 20 |
| 28862946 | 2017 | α(1)-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells. | 20 |
| 26621245 | 2016 | A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro". | 4 |
| 26739946 | 2016 | Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate. | 2 |
| 27146292 | 2016 | Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway. | 1 |
Citation
Dessen P
ADRA1D (adrenoceptor alpha 1D)
Atlas Genet Cytogenet Oncol Haematol. 2015-08-01
Online version: http://atlasgeneticsoncology.org/gene/55369/adra1d-(adrenoceptor-alpha-1d)
