CNOT4 (CCR4-NOT transcription complex subunit 4)

2015-08-01  

Identity

HGNC
CNOT4
LOCATION
7q33
LOCUSID
4850
ALIAS
CLONE243,NOT4,NOT4H
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4850
MIM: 604911
HGNC: 7880
Ensembl: ENSG00000080802

Variants:

dbSNP: 4850
ClinVar: 4850
TCGA: ENSG00000080802
COSMIC: CNOT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080802ENST00000315544O95628
ENSG00000080802ENST00000315544A0A024R785
ENSG00000080802ENST00000356162A0A0A0MRD2
ENSG00000080802ENST00000361528O95628
ENSG00000080802ENST00000414802O95628
ENSG00000080802ENST00000423368O95628
ENSG00000080802ENST00000423368A0A024R781
ENSG00000080802ENST00000428680O95628
ENSG00000080802ENST00000428680A0A024R776
ENSG00000080802ENST00000451834O95628
ENSG00000080802ENST00000541284O95628

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374931052023CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1.2
374931052023CNOT4 suppresses nonsmall cell lung cancer progression by promoting the degradation of PAF1.2
334511392021The Interplay between HGF/c-met Axis and Nox4 in BRAF Mutated Melanoma.3
335925722021CNOT4 suppresses non-small cell lung cancer progression and is required for effector cytolytic T lymphocytes cell responses to lung cancer cells.1
346260222021Aberrant expression of MYD88 via RNA-controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer.3
334511392021The Interplay between HGF/c-met Axis and Nox4 in BRAF Mutated Melanoma.3
335925722021CNOT4 suppresses non-small cell lung cancer progression and is required for effector cytolytic T lymphocytes cell responses to lung cancer cells.1
346260222021Aberrant expression of MYD88 via RNA-controlling CNOT4 and EXOSC3 in colonic mucosa impacts generation of colonic cancer.3
330341492020CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer.1
330341492020CNOT4 enhances the efficacy of anti-PD-1 immunotherapy in a model of non-small cell lung cancer.1
306922042019A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.25
306922042019A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.25
298023282018The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.9
298613912018Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy.29
298023282018The conserved RNA recognition motif and C3H1 domain of the Not4 ubiquitin ligase regulate in vivo ligase function.9

Citation

Dessen P

CNOT4 (CCR4-NOT transcription complex subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55380/haematological-explorer/tumors-explorer/hgnc