DDIAS (DNA damage induced apoptosis suppressor)

2015-09-01  

Identity

HGNC
DDIAS
LOCATION
11q14.1
LOCUSID
220042
ALIAS
C11orf82,noxin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 220042
MIM: 618045
HGNC: 26351
Ensembl: ENSG00000165490

Variants:

dbSNP: 220042
ClinVar: 220042
TCGA: ENSG00000165490
COSMIC: DDIAS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165490ENST00000329143Q8IXT1
ENSG00000165490ENST00000524921B4DS54
ENSG00000165490ENST00000525361Q8IXT1
ENSG00000165490ENST00000525388B4DS54
ENSG00000165490ENST00000528262E9PN94
ENSG00000165490ENST00000528759E9PM93
ENSG00000165490ENST00000532277E9PLJ5
ENSG00000165490ENST00000532589E9PQP9
ENSG00000165490ENST00000532764E9PMA7
ENSG00000165490ENST00000533655Q8IXT1

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
264937272016DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer.12
274129112016DNA damage induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion.11
280798822017Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells.7
292426052018DDIAS suppresses TRAIL-mediated apoptosis by inhibiting DISC formation and destabilizing caspase-8 in cancer cells.6
256128322015NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma.4
286189632017Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway.2

Citation

Dessen P

DDIAS (DNA damage induced apoptosis suppressor)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55393/ddias-(dna-damage-induced-apoptosis-suppressor)