HCRT (hypocretin neuropeptide precursor)

2015-09-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
NRCLP1,OX,PPOX

Other Information

Locus ID:

NCBI: 3060
MIM: 602358
HGNC: 4847
Ensembl: ENSG00000161610

Variants:

dbSNP: 3060
ClinVar: 3060
TCGA: ENSG00000161610
COSMIC: HCRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161610ENST00000293330O43612

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375729902024Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.0
381088662024The role of orexin in fatigue and sleep quality in patients with primary Sjögren's syndrome.0
382409112024Bi-allelic variants in HCRT cause autosomal recessive narcolepsy.0
386856742024Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion.1
388924312024Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease.0
375729902024Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.0
381088662024The role of orexin in fatigue and sleep quality in patients with primary Sjögren's syndrome.0
382409112024Bi-allelic variants in HCRT cause autosomal recessive narcolepsy.0
386856742024Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion.1
388924312024Increased Expression of Orexin-A in Patients Affected by Polycystic Kidney Disease.0
364006672023How hypocretin agonists may improve the quality of wake in narcolepsy.1
368920782023Attenuation of Hypocretin/Orexin Signaling Is Associated With Increased Mortality After Myocardial Infarction.0
369774332023Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.1
370548952023Internal and external modulation factors of the orexin system (REVIEW).3
371550182023Orexin pathway in Parkinson's disease: a review.5

Citation

Dessen P

HCRT (hypocretin neuropeptide precursor)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55398/hcrt-(hypocretin-neuropeptide-precursor)