SLC8A1 (solute carrier family 8 member A1)

2015-09-01  

Identity

HGNC
LOCATION
2p22.1
LOCUSID
ALIAS
NCX1
FUSION GENES

Other Information

Locus ID:

NCBI: 6546
MIM: 182305
HGNC: 11068
Ensembl: ENSG00000183023

Variants:

dbSNP: 6546
ClinVar: 6546
TCGA: ENSG00000183023
COSMIC: SLC8A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183023ENST00000332839P32418
ENSG00000183023ENST00000402441P32418
ENSG00000183023ENST00000403092P32418
ENSG00000183023ENST00000405269P32418
ENSG00000183023ENST00000405901P32418
ENSG00000183023ENST00000406391P32418
ENSG00000183023ENST00000406785P32418
ENSG00000183023ENST00000407929E7EV41
ENSG00000183023ENST00000408028P32418
ENSG00000183023ENST00000417271E9PB98
ENSG00000183023ENST00000448531E9PCL8
ENSG00000183023ENST00000455476E9PCL8

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Olfactory transductionKEGGko04740
Calcium signaling pathwayKEGGhsa04020
Olfactory transductionKEGGhsa04740
Cardiac muscle contractionKEGGhsa04260
Cardiac muscle contractionKEGGko04260
Hypertrophic cardiomyopathy (HCM)KEGGko05410
Hypertrophic cardiomyopathy (HCM)KEGGhsa05410
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Dilated cardiomyopathyKEGGko05414
Dilated cardiomyopathyKEGGhsa05414
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Reduction of cytosolic Ca++ levelsREACTOMER-HSA-418359
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Sodium/Calcium exchangersREACTOMER-HSA-425561
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381773132024Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.3
381773132024Structural insight into the allosteric inhibition of human sodium-calcium exchanger NCX1 by XIP and SEA0400.3
362511452023NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.1
370744532023Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.0
377940112023Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.8
379661642023LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.3
362511452023NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma.1
370744532023Association of polymorphisms of calcium reabsorption genes SLC12A1, KCNJ1 and SLC8A1 with colorectal adenoma.0
377940112023Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.8
379661642023LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition.3
358829792022NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.3
358941572022Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.1
358829792022NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.3
358941572022Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.1
333018952021circSLC8A1 sponges miR-671 to regulate breast cancer tumorigenesis via PTEN/PI3k/Akt pathway.11

Citation

Dessen P

SLC8A1 (solute carrier family 8 member A1)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55403/slc8a1-(solute-carrier-family-8-member-a1)