Identity
HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
GLYA,HEL-S-51e,NEDCASB,SHMT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 6472
MIM: 138450
HGNC: 10852
Ensembl: ENSG00000182199
Variants:
dbSNP: 6472
ClinVar: 6472
TCGA: ENSG00000182199
COSMIC: SHMT2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37983722 | 2024 | YTHDF1 enhances stemness and chemoresistance in triple-negative breast cancer cells by upregulating SIAH2. | 2 |
| 38188143 | 2024 | The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer. | 0 |
| 38460155 | 2024 | Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma. | 1 |
| 37983722 | 2024 | YTHDF1 enhances stemness and chemoresistance in triple-negative breast cancer cells by upregulating SIAH2. | 2 |
| 38188143 | 2024 | The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer. | 0 |
| 38460155 | 2024 | Phosphorylated SHMT2 Regulates Oncogenesis Through m(6)A Modification in Lung Adenocarcinoma. | 1 |
| 36806313 | 2023 | Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming. | 4 |
| 36917325 | 2023 | MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2. | 0 |
| 37108312 | 2023 | SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling. | 2 |
| 37742129 | 2023 | NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2. | 0 |
| 36806313 | 2023 | Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming. | 4 |
| 36917325 | 2023 | MiR-24-1-5p Hinders Malignant Phenotypes of Clear Cell Renal Cell Carcinoma by Targeting SHOX2. | 0 |
| 37108312 | 2023 | SHMT2 Promotes Gastric Cancer Development through Regulation of HIF1α/VEGF/STAT3 Signaling. | 2 |
| 37742129 | 2023 | NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2. | 0 |
| 34624079 | 2022 | SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. | 16 |
Citation
Dessen P
SHMT2 (serine hydroxymethyltransferase 2)
Atlas Genet Cytogenet Oncol Haematol. 2015-10-01
Online version: http://atlasgeneticsoncology.org/gene/55419/
