FBXW11 (F-box and WD repeat domain containing 11)

2015-10-01  

Identity

HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
BTRC2,BTRCP2,FBW1B,FBXW1B,Fbw11,Hos,NEDJED
FUSION GENES

Other Information

Locus ID:

NCBI: 23291
MIM: 605651
HGNC: 13607
Ensembl: ENSG00000072803

Variants:

dbSNP: 23291
ClinVar: 23291
TCGA: ENSG00000072803
COSMIC: FBXW11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072803ENST00000265094Q9UKB1
ENSG00000072803ENST00000296933Q9UKB1
ENSG00000072803ENST00000393802Q9UKB1
ENSG00000072803ENST00000517395E5RGC1
ENSG00000072803ENST00000518752E5RH92
ENSG00000072803ENST00000519693E5RG78
ENSG00000072803ENST00000520376E5RG78
ENSG00000072803ENST00000523843E5RG78

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Wnt signaling pathwayKEGGko04310
Hedgehog signaling pathwayKEGGko04340
Circadian rhythmKEGGko04710
Ubiquitin mediated proteolysisKEGGhsa04120
Wnt signaling pathwayKEGGhsa04310
Hedgehog signaling pathwayKEGGhsa04340
Circadian rhythmKEGGhsa04710
ShigellosisKEGGhsa05131
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
SCF-BTRC complexKEGGhsa_M00380
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
SCF-BTRC complexKEGGM00380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Downstream TCR signalingREACTOMER-HSA-202424
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
Activation of NF-kappaB in B cellsREACTOMER-HSA-1169091
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated NF-kB activationREACTOMER-HSA-2871837
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CLEC7A (Dectin-1) signalingREACTOMER-HSA-5607764
Dectin-1 mediated noncanonical NF-kB signalingREACTOMER-HSA-5607761
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-1 signalingREACTOMER-HSA-446652
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
NIK-->noncanonical NF-kB signalingREACTOMER-HSA-5676590
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
MAP3K8 (TPL2)-dependent MAPK1/3 activationREACTOMER-HSA-5684264

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381820682024E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.0
381820682024E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.0
371990762023Expression of FBXW11 in normal and disease-associated osteogenic cells.4
371990762023Expression of FBXW11 in normal and disease-associated osteogenic cells.4
355828962022F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A.1
364045342022Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.4
355828962022F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A.1
364045342022Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.4
330210362021The characteristics and roles of β-TrCP1/2 in carcinogenesis.23
331319252021MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling.10
346423022021FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer.15
330210362021The characteristics and roles of β-TrCP1/2 in carcinogenesis.23
331319252021MicroRNA-221 Promotes Cell Proliferation and Inhibits Apoptosis in Osteosarcoma Cells by Directly Targeting FBXW11 and Regulating Wnt Signaling.10
346423022021FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer.15
314020902019De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies.18

Citation

Dessen P

FBXW11 (F-box and WD repeat domain containing 11)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55423/