NAGLU (N-acetyl-alpha-glucosaminidase)

2015-10-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
CMT2V,MPS-IIIB,MPS3B,NAG,UFHSD
FUSION GENES

Other Information

Locus ID:

NCBI: 4669
MIM: 609701
HGNC: 7632
Ensembl: ENSG00000108784

Variants:

dbSNP: 4669
ClinVar: 4669
TCGA: ENSG00000108784
COSMIC: NAGLU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108784ENST00000225927P54802
ENSG00000108784ENST00000225927A0A140VJE4
ENSG00000108784ENST00000586516K7ENX5
ENSG00000108784ENST00000590358K7END1
ENSG00000108784ENST00000591587K7EQH9
ENSG00000108784ENST00000592454K7ESD7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glycosaminoglycan degradationKEGGko00531
Glycosaminoglycan degradationKEGGhsa00531
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolic pathwaysKEGGhsa01100
Heparan sulfate degradationKEGGhsa_M00078
Heparan sulfate degradationKEGGM00078
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
HS-GAG degradationREACTOMER-HSA-2024096

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
352414682022Variations of urinary N-acetyl-β-D-glucosaminidase levels and its performance in detecting acute kidney injury under different thyroid hormones levels: a prospectively recruited, observational study.3
352414682022Variations of urinary N-acetyl-β-D-glucosaminidase levels and its performance in detecting acute kidney injury under different thyroid hormones levels: a prospectively recruited, observational study.3
318258162020Generation of two NAGLU-mutated homozygous cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo B syndrome.2
318258162020Generation of two NAGLU-mutated homozygous cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo B syndrome.2
308025062019Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.7
308025062019Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.7
296060972018Mucopolysaccharidosis IIIB and mild skeletal anomalies: coexistence of NAGLU and CYP26B1 missense variations in the same patient in a Chinese family.5
299551332018Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.21
296060972018Mucopolysaccharidosis IIIB and mild skeletal anomalies: coexistence of NAGLU and CYP26B1 missense variations in the same patient in a Chinese family.5
299551332018Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer.21
283065362017Molecular defects identified by whole exome sequencing in a child with atypical mucopolysaccharidosis IIIB.8
287511082017Processing of mutant N-acetyl-α-glucosaminidase in mucopolysaccharidosis type IIIB fibroblasts cultured at low temperature.3
283065362017Molecular defects identified by whole exome sequencing in a child with atypical mucopolysaccharidosis IIIB.8
287511082017Processing of mutant N-acetyl-α-glucosaminidase in mucopolysaccharidosis type IIIB fibroblasts cultured at low temperature.3
275909252016A prospective one-year natural history study of mucopolysaccharidosis types IIIA and IIIB: Implications for clinical trial design.16

Citation

Dessen P

NAGLU (N-acetyl-alpha-glucosaminidase)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55438/naglu-(n-acetyl-alpha-glucosaminidase)