SLF2 (SMC5-SMC6 complex localization factor 2)

2015-10-01  

Identity

HGNC
LOCATION
10q24.31
LOCUSID
ALIAS
C10orf6,FAM178A

Other Information

Locus ID:

NCBI: 55719
MIM: 610348
HGNC: 17814
Ensembl: ENSG00000119906

Variants:

dbSNP: 55719
ClinVar: 55719
TCGA: ENSG00000119906
COSMIC: SLF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119906ENST00000238961Q8IX21
ENSG00000119906ENST00000370269Q8IX21
ENSG00000119906ENST00000370271B1AL16
ENSG00000119906ENST00000609386Q8IX21
ENSG00000119906ENST00000649226A0A3B3IRS8

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
374858142023Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.2
374858142023Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response.2
363333052022Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.11
363333052022Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy.11
347804832021ATRX proximal protein associations boast roles beyond histone deposition.7
347804832021ATRX proximal protein associations boast roles beyond histone deposition.7
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.83

Citation

Dessen P

SLF2 (SMC5-SMC6 complex localization factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55451/slf2-(smc5-smc6-complex-localization-factor-2)