CLIP3 (CAP-Gly domain containing linker protein 3)

2015-10-01  

Identity

HGNC
CLIP3
LOCATION
19q13.12
LOCUSID
25999
ALIAS
CLIPR-59,CLIPR59,RSNL1

Other Information

Locus ID:

NCBI: 25999
MIM: 607382
HGNC: 24314
Ensembl: ENSG00000105270

Variants:

dbSNP: 25999
ClinVar: 25999
TCGA: ENSG00000105270
COSMIC: CLIP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105270ENST00000360535Q96DZ5
ENSG00000105270ENST00000590559K7ESF3
ENSG00000105270ENST00000592017K7ESF3
ENSG00000105270ENST00000593074Q96DZ5

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
Regulation of TNFR1 signalingREACTOMER-HSA-5357905

References

Pubmed IDYearTitleCitations
118543072002CLIPR-59, a new trans-Golgi/TGN cytoplasmic linker protein belonging to the CLIP-170 family.18
240017712013DHHC17 palmitoylates ClipR-59 and modulates ClipR-59 association with the plasma membrane.15
222972962012CLIPR-59 regulates TNF-α-induced apoptosis by controlling ubiquitination of RIP1.13
152629902004CLIPR-59 is a lipid raft-associated protein containing a cytoskeleton-associated protein glycine-rich domain (CAP-Gly) that perturbs microtubule dynamics.12
200522882010Role of GD3-CLIPR-59 association in lymphoblastoid T cell apoptosis triggered by CD95/Fas.8
260176712015Spy1 induces de-ubiquitinating of RIP1 arrest and confers glioblastoma's resistance to tumor necrosis factor (TNF-α)-induced apoptosis through suppressing the association of CLIPR-59 and CYLD.2
276138192016MicroRNA-593-3p regulates insulin-promoted glucose consumption by targeting Slc38a1 and CLIP3.1

Citation

Dessen P

CLIP3 (CAP-Gly domain containing linker protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55458/clip3-(cap-gly-domain-containing-linker-protein-3)