Identity
HGNC
LOCATION
5p15.2
LOCUSID
ALIAS
AIPDS,FAM105B,GUM
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 90268
MIM: 615712
HGNC: 25118
Ensembl: ENSG00000154124
Variants:
dbSNP: 90268
ClinVar: 90268
TCGA: ENSG00000154124
COSMIC: OTULIN
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000154124 | ENST00000284274 | Q96BN8 |
| ENSG00000154124 | ENST00000503023 | D6RD57 |
| ENSG00000154124 | ENST00000506417 | H0Y9T0 |
| ENSG00000154124 | ENST00000514913 | H0Y8S4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38578307 | 2024 | OTULIN Haploinsufficiency Causes Hyperinflammatory Responses to Infectious and Non-Infectious Triggers. | 0 |
| 38578307 | 2024 | OTULIN Haploinsufficiency Causes Hyperinflammatory Responses to Infectious and Non-Infectious Triggers. | 0 |
| 37589075 | 2023 | An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity. | 1 |
| 38062820 | 2023 | Integrated Single-Cell and Transcriptome Sequencing Analyses Develop a Ubiquitination-Associated Signature in Gastric Cancer and Identified OTULIN as a Novel Biomarker. | 1 |
| 37589075 | 2023 | An interaction between OTULIN and SCRIB uncovers roles for linear ubiquitination in planar cell polarity. | 1 |
| 38062820 | 2023 | Integrated Single-Cell and Transcriptome Sequencing Analyses Develop a Ubiquitination-Associated Signature in Gastric Cancer and Identified OTULIN as a Novel Biomarker. | 1 |
| 35587511 | 2022 | Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin. | 19 |
| 35939695 | 2022 | Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses. | 1 |
| 35587511 | 2022 | Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin. | 19 |
| 35939695 | 2022 | Reciprocal interplay between OTULIN-LUBAC determines genotoxic and inflammatory NF-κB signal responses. | 1 |
| 32543267 | 2021 | LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13. | 25 |
| 32543267 | 2021 | LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13. | 25 |
| 32231246 | 2020 | OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer. | 38 |
| 32770022 | 2020 | ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers. | 28 |
| 32231246 | 2020 | OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer. | 38 |
Citation
Dessen P
OTULIN (OTU deubiquitinase with linear linkage specificity)
Atlas Genet Cytogenet Oncol Haematol. 2015-10-01
Online version: http://atlasgeneticsoncology.org/gene/55461/tumors-explorer/
