TIPIN (TIMELESS interacting protein)

2015-10-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 54962
MIM: 610716
HGNC: 30750
Ensembl: ENSG00000075131

Variants:

dbSNP: 54962
ClinVar: 54962
TCGA: ENSG00000075131
COSMIC: TIPIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075131ENST00000261881Q9BVW5
ENSG00000075131ENST00000562124H3BU04
ENSG00000075131ENST00000566524H3BQ83
ENSG00000075131ENST00000568216H3BTH1
ENSG00000075131ENST00000570251H3BVG9

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
346891702022Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.0
346891702022Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer.0
283347662017Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.8
283347662017Crystal structure of the N-terminal domain of human Timeless and its interaction with Tipin.8
260040862015TIPIN depletion leads to apoptosis in breast cancer cells.18
260040862015TIPIN depletion leads to apoptosis in breast cancer cells.18
233596762013Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.45
235116382013The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.10
233596762013Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.45
235116382013The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.10
214901032011The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus.17
214901032011The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus.17
201244172010Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.84
201746232010Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.38
202337252010Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.74

Citation

Dessen P

TIPIN (TIMELESS interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55466/tipin-(timeless-interacting-protein)