PLPP5 (phospholipid phosphatase 5)

2015-10-01  

Identity

HGNC
PLPP5
LOCATION
8p11.23
LOCUSID
84513
ALIAS
DPPL1,HTPAP,PPAPDC1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84513
MIM: 610626
HGNC: 25026
Ensembl: ENSG00000147535

Variants:

dbSNP: 84513
ClinVar: 84513
TCGA: ENSG00000147535
COSMIC: PLPP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147535ENST00000419686Q8NEB5
ENSG00000147535ENST00000422581Q8NEB5
ENSG00000147535ENST00000424479Q8NEB5
ENSG00000147535ENST00000424479A0A140VK38
ENSG00000147535ENST00000524616H0YCQ3
ENSG00000147535ENST00000529359Q8NEB5
ENSG00000147535ENST00000531109H0YDY2
ENSG00000147535ENST00000531823E9PNB1
ENSG00000147535ENST00000534339H0YCK0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485

References

Pubmed IDYearTitleCitations
246034122014Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.1
246034122014Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.1
240510132013PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.20
240510132013PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.20
212195412011Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma.2
215317642011Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma.6
212195412011Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma.2
215317642011Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma.6
187574322008Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.42
187574322008Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.42
175905382007Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.8
175905382007Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.8
162611602006HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.12
162611602006HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.12

Citation

Dessen P

PLPP5 (phospholipid phosphatase 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55473/plpp5-(phospholipid-phosphatase-5)