RNF185 (ring finger protein 185)

2015-10-01 Affiliation

Identity

HGNC

RNF185

LOCATION

22q12.2

LOCUSID

91445

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 91445
HGNC: 26783
Ensembl: ENSG00000138942

Variants:

dbSNP: 91445
ClinVar: 91445
TCGA: ENSG00000138942
COSMIC: RNF185

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000138942	ENST00000266252	Q96GF1
ENSG00000138942	ENST00000266252	A0A024R1H4
ENSG00000138942	ENST00000326132	Q96GF1
ENSG00000138942	ENST00000326132	A0A024R1F5
ENSG00000138942	ENST00000426256	A9X3U0
ENSG00000138942	ENST00000518626	Q96GF1
ENSG00000138942	ENST00000518626	A0A024R1F5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein processing in endoplasmic reticulum	KEGG	ko04141
Protein processing in endoplasmic reticulum	KEGG	hsa04141
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	REACTOME	R-HSA-532668
Calnexin/calreticulin cycle	REACTOME	R-HSA-901042
ER Quality Control Compartment (ERQC)	REACTOME	R-HSA-901032
Disease	REACTOME	R-HSA-1643685
Disorders of transmembrane transporters	REACTOME	R-HSA-5619115
ABC transporter disorders	REACTOME	R-HSA-5619084
Defective CFTR causes cystic fibrosis	REACTOME	R-HSA-5678895
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
ABC-family proteins mediated transport	REACTOME	R-HSA-382556

References

Pubmed ID	Year	Title	Citations
21931693	2011	RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1.	33
28273161	2017	The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.	26
24019521	2013	RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR).	24
24727453	2014	The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation.	4
29481911	2018	RNF185 modulates JWA ubiquitination and promotes gastric cancer metastasis.	4

Citation

Dessen P

RNF185 (ring finger protein 185)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55476/rnf185-(ring-finger-protein-185)