RNMT (RNA guanine-7 methyltransferase)

2015-10-01  

Identity

HGNC
LOCATION
18p11.21
LOCUSID
ALIAS
CMT1,CMT1c,MET,Met,RG7MT1,cm1p,hCMT1,hMet
FUSION GENES

Other Information

Locus ID:

NCBI: 8731
MIM: 603514
HGNC: 10075
Ensembl: ENSG00000101654

Variants:

dbSNP: 8731
ClinVar: 8731
TCGA: ENSG00000101654
COSMIC: RNMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101654ENST00000262173O43148
ENSG00000101654ENST00000383314O43148
ENSG00000101654ENST00000543302O43148
ENSG00000101654ENST00000588457K7EP06
ENSG00000101654ENST00000589866O43148
ENSG00000101654ENST00000591746K7EPP5
ENSG00000101654ENST00000592764O43148
ENSG00000101654ENST00000593007K7ERH6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionREACTOMER-HSA-167160
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Pol II CTD phosphorylation and interaction with CEREACTOMER-HSA-77075
mRNA CappingREACTOMER-HSA-72086

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384022662024Kinetic characterization of human mRNA guanine-N7 methyltransferase.0
384022662024Kinetic characterization of human mRNA guanine-N7 methyltransferase.0
350262302022Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E.17
350262302022Identification and Characterization of the Interaction Between the Methyl-7-Guanosine Cap Maturation Enzyme RNMT and the Cap-Binding Protein eIF4E.17
309919342019Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells.15
313299322019Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations.13
309919342019Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells.15
313299322019Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations.13
297192632018mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription.23
297192632018mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription.23
278994232017MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.22
279346332017c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production.6
289817152017RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs.45
278994232017MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase.22
279346332017c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production.6

Citation

Dessen P

RNMT (RNA guanine-7 methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55481/rnmt-(rna-guanine-7-methyltransferase)