ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase)

2015-10-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
DMS-8,DSM-8,DSM8,FKSG11,PZF,ZFP-91,ZNF757
FUSION GENES

Other Information

Locus ID:

NCBI: 80829
HGNC: 14983
Ensembl: ENSG00000186660

Variants:

dbSNP: 80829
ClinVar: 80829
TCGA: ENSG00000186660
COSMIC: ZFP91

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186660ENST00000316059Q96JP5
ENSG00000186660ENST00000316059A0A024R4Z1

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
349366962022Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.8
349423112022Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.4
363753172022Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.9
349366962022Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.8
349423112022Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.4
363753172022Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.9
337552682021Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer.6
344033612021ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.9
337552682021Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer.6
344033612021ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.9
310461162020The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.13
326306702020Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.8
327542632020E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.30
329454992020MicroRNA‑188‑5p inhibits the progression of breast cancer by targeting zinc finger protein 91.4
310461162020The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.13

Citation

Dessen P

ZFP91 (ZFP91 zinc finger protein, atypical E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2015-10-01

Online version: http://atlasgeneticsoncology.org/gene/55499/zfp91-(zfp91-zinc-finger-protein-atypical-e3-ubiquitin-ligase)