MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1)

2015-12-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
MICAL,MICAL-1,NICAL
FUSION GENES

Other Information

Locus ID:

NCBI: 64780
MIM: 607129
HGNC: 20619
Ensembl: ENSG00000135596

Variants:

dbSNP: 64780
ClinVar: 64780
TCGA: ENSG00000135596
COSMIC: MICAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135596ENST00000358577Q8TDZ2
ENSG00000135596ENST00000358807Q8TDZ2
ENSG00000135596ENST00000431946Q5TED7
ENSG00000135596ENST00000433205H0Y6Z4
ENSG00000135596ENST00000630715Q8TDZ2

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385084742024PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.0
385084742024PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.0
349023392022MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.7
353793542022Mical modulates Tau toxicity via cysteine oxidation in vivo.5
365754392022High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.0
349023392022MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.7
353793542022Mical modulates Tau toxicity via cysteine oxidation in vivo.5
365754392022High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.0
343147532021MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.5
343147532021MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.5
323444332020GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.17
327492372020MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.18
323444332020GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.17
327492372020MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.18
302429332019Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.4

Citation

Dessen P

MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-12-01

Online version: http://atlasgeneticsoncology.org/gene/55540/mical1-(microtubule-associated-monooxygenase-calponin-and-lim-domain-containing-1)