SEMA6A (semaphorin 6A)

2015-12-01  

Identity

HGNC
SEMA6A
LOCATION
5q23.1
LOCUSID
57556
ALIAS
HT018,SEMA,SEMA6A1,SEMAQ,VIA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57556
MIM: 605885
HGNC: 10738
Ensembl: ENSG00000092421

Variants:

dbSNP: 57556
ClinVar: 57556
TCGA: ENSG00000092421
COSMIC: SEMA6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092421ENST00000257414A0A0A0MQU6
ENSG00000092421ENST00000343348Q9H2E6
ENSG00000092421ENST00000503865E9PDV9
ENSG00000092421ENST00000509665D6RCR0
ENSG00000092421ENST00000510263Q9H2E6
ENSG00000092421ENST00000513137B3KU01
ENSG00000092421ENST00000515009D6RAG9
ENSG00000092421ENST00000515129H0Y8V9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
Other semaphorin interactionsREACTOMER-HSA-416700

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221844112012MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A.76
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195788762009The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.39
237407752013Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.31
255769232015Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells.19
176717482007Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells.16
181878092008From plasma membrane to cytoskeleton: a novel function for semaphorin 6A.10
164366602006The class 6 semaphorin SEMA6A is induced by interferon-gamma and defines an activation status of langerhans cells observed in pathological situations.8
260145172015SEMA6A is a prognostic biomarker in glioblastoma.6
289828522017Suppression of Oral Carcinoma Oncogenic Activity by microRNA-203 via Down-regulation of SEMA6A.2

Citation

Dessen P

SEMA6A (semaphorin 6A)

Atlas Genet Cytogenet Oncol Haematol. 2015-12-01

Online version: http://atlasgeneticsoncology.org/gene/55554/sema6a-(semaphorin-6a)