MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)

2016-01-01 Affiliation

Identity

HGNC

MAF1

LOCATION

8q24.3

LOCUSID

84232

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84232
MIM: 610210
HGNC: 24966
Ensembl: ENSG00000179632

Variants:

dbSNP: 84232
ClinVar: 84232
TCGA: ENSG00000179632
COSMIC: MAF1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179632	ENST00000322428	Q9H063
ENSG00000179632	ENST00000527058	E9PR76
ENSG00000179632	ENST00000527572	E9PJ05
ENSG00000179632	ENST00000532522	Q9H063
ENSG00000179632	ENST00000534585	E9PSH4
ENSG00000179632	ENST00000534811	H0YEV4

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
33640883	2021	Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549.	7
33640883	2021	Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549.	7
32066962	2020	Structural basis for RNA polymerase III transcription repression by Maf1.	21
32066962	2020	Structural basis for RNA polymerase III transcription repression by Maf1.	21
30628658	2019	Involvement of MAF1 homolog, negative regulator of RNA polymerase III in colorectal cancer progression.	8
31645432	2019	The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.	7
30628658	2019	Involvement of MAF1 homolog, negative regulator of RNA polymerase III in colorectal cancer progression.	8
31645432	2019	The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.	7
26910647	2016	MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.	41
26941251	2016	Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.	42
26910647	2016	MAF1 suppresses AKT-mTOR signaling and liver cancer through activation of PTEN transcription.	41
26941251	2016	Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.	42
25568945	2015	Regulating maf1 expression and its expanding biological functions.	6
26030842	2015	A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells.	14
26067234	2015	MAF1 represses CDKN1A through a Pol III-dependent mechanism.	13

Citation

Dessen P

MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55576/css/lib/hgnc