Identity
HGNC
LOCATION
3p21.1
LOCUSID
ALIAS
CMD1Z,CMH13,TN-C,TNC,TNNC
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7134
MIM: 191040
HGNC: 11943
Ensembl: ENSG00000114854
Variants:
dbSNP: 7134
ClinVar: 7134
TCGA: ENSG00000114854
COSMIC: TNNC1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000114854 | ENST00000232975 | P63316 |
| ENSG00000114854 | ENST00000232975 | Q6FH91 |
| ENSG00000114854 | ENST00000496590 | C9JDI3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38871035 | 2024 | Troponin C gene mutations on cardiac muscle cell and skeletal Regulation: A comprehensive review. | 0 |
| 38871035 | 2024 | Troponin C gene mutations on cardiac muscle cell and skeletal Regulation: A comprehensive review. | 0 |
| 34797443 | 2022 | Troponin C-1 Activated by E2F1 Accelerates Gastric Cancer Progression via Regulating TGF-β/Smad Signaling. | 1 |
| 34797443 | 2022 | Troponin C-1 Activated by E2F1 Accelerates Gastric Cancer Progression via Regulating TGF-β/Smad Signaling. | 1 |
| 33242510 | 2021 | Interpretation of elevated high-sensitivity cardiac troponin I in elite soccer players previously infected by severe acute respiratory syndrome coronavirus 2. | 18 |
| 33548225 | 2021 | Binding of calcium and magnesium to human cardiac troponin C. | 9 |
| 33592378 | 2021 | TNNC1 knockout reverses metastatic potential of ovarian cancer cells by inactivating epithelial-mesenchymal transition and suppressing F-actin polymerization. | 3 |
| 33901537 | 2021 | Dilated Cardiomyopathy Mutations and Phosphorylation disrupt the Active Orientation of Cardiac Troponin C. | 5 |
| 34502534 | 2021 | De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents. | 6 |
| 33242510 | 2021 | Interpretation of elevated high-sensitivity cardiac troponin I in elite soccer players previously infected by severe acute respiratory syndrome coronavirus 2. | 18 |
| 33548225 | 2021 | Binding of calcium and magnesium to human cardiac troponin C. | 9 |
| 33592378 | 2021 | TNNC1 knockout reverses metastatic potential of ovarian cancer cells by inactivating epithelial-mesenchymal transition and suppressing F-actin polymerization. | 3 |
| 33901537 | 2021 | Dilated Cardiomyopathy Mutations and Phosphorylation disrupt the Active Orientation of Cardiac Troponin C. | 5 |
| 34502534 | 2021 | De Novo Missense Mutations in TNNC1 and TNNI3 Causing Severe Infantile Cardiomyopathy Affect Myofilament Structure and Function and Are Modulated by Troponin Targeting Agents. | 6 |
| 32638704 | 2020 | Characterization of TNNC1 as a Novel Tumor Suppressor of Lung Adenocarcinoma. | 9 |
Citation
Dessen P
TNNC1 (troponin C1, slow skeletal and cardiac type)
Atlas Genet Cytogenet Oncol Haematol. 2016-01-01
Online version: http://atlasgeneticsoncology.org/gene/55584/teaching-explorer/gene-fusions/tumors-explorer/cancer-prone-explorer/
