GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)

2016-01-01 Affiliation

Identity

HGNC

GRIN3A

LOCATION

9q31.1

LOCUSID

116443

ALIAS

GluN3A,NMDAR-L,NMDAR3A,NR3A

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 116443
MIM: 606650
HGNC: 16767
Ensembl: ENSG00000198785

Variants:

dbSNP: 116443
ClinVar: 116443
TCGA: ENSG00000198785
COSMIC: GRIN3A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198785	ENST00000361820	Q8TCU5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Nicotine addiction	KEGG	hsa05033
Nicotine addiction	KEGG	ko05033
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA445876	Tobacco Use Disorder	Disease	ClinicalAnnotation	associated			20084518
PA450626	nicotine	Chemical	ClinicalAnnotation	associated			20084518

References

Pubmed ID	Year	Title	Citations
36898314	2023	Correlations between GRIN2B and GRIN3A gene polymorphisms and postpartum depressive symptoms in Chinese parturients undergoing cesarean section: A prospective cohort study.	1
37248111	2023	Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling.	3
36898314	2023	Correlations between GRIN2B and GRIN3A gene polymorphisms and postpartum depressive symptoms in Chinese parturients undergoing cesarean section: A prospective cohort study.	1
37248111	2023	Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling.	3
34151525	2022	Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A.	12
34151525	2022	Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A.	12
30741440	2020	Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.	6
30741440	2020	Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.	6
29678681	2019	Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.	5
31444392	2019	Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors.	13
29678681	2019	Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians.	5
31444392	2019	Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors.	13
27542340	2016	Association between genetic variations of NMDA receptor NR3 subfamily genes and heroin addiction in male Han Chinese.	5
27558536	2016	Emerging roles of GluN3-containing NMDA receptors in the CNS.	84
27840953	2016	GRIN3A and MAPT stimulate nerve overgrowth in macrodactyly.	3

Citation

Dessen P

GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55598/grin3a-(glutamate-ionotropic-receptor-nmda-type-subunit-3a)