Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3358
MIM: 312861
HGNC: 5295
Ensembl: ENSG00000147246
Variants:
dbSNP: 3358
ClinVar: 3358
TCGA: ENSG00000147246
COSMIC: HTR2C
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000147246 | ENST00000276198 | P28335 |
| ENSG00000147246 | ENST00000371950 | P28335 |
| ENSG00000147246 | ENST00000371951 | P28335 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10074 | escitalopram | Chemical | ClinicalAnnotation | associated | PD | 21614492 | |
| PA128406954 | Weight gain | Disease | ClinicalAnnotation, MultilinkAnnotation, VariantAnnotation | associated | PD | 17016522, 17632216, 17702092, 19193342, 19434072, 19997080, 20504252, 21121776, 22967772, 24279860, 26880915, 27217270 | |
| PA162263525 | neuropathic pain | Disease | ClinicalAnnotation | associated | PD | 21614492 | |
| PA162370415 | Metabolic Syndrome | Disease | ClinicalAnnotation | associated | PD | 17632216, 19142101, 20680028, 25152019 | |
| PA162565877 | amisulpride | Chemical | VariantAnnotation | associated | PD | 20504252 | |
| PA166123368 | schizoaffective disorder | Disease | VariantAnnotation | associated | PD | 20504252 | |
| PA174 | GNAQ | Gene | Pathway | associated | 19741567 | ||
| PA447208 | Mental Disorders | Disease | ClinicalAnnotation | associated | PD | 15635667, 15666332, 16633140, 17016522, 17702092, 18718676, 19193342, 19434072, 19636338, 20504252, 21121776, 21510767, 22967772, 25152019 | |
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 17016522, 17632216, 17702092, 19142101, 19193342, 19434072, 19997080, 20504252, 20680028, 21121776, 22967772, 25152019, 26880915, 27217270 | |
| PA449061 | clozapine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 17016522, 17632216, 19142101, 19434072, 20504252, 20680028, 21121776, 22967772, 25152019 | |
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA450688 | olanzapine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 17016522, 17632216, 17702092, 19142101, 19193342, 19434072, 19997080, 20504252, 20680028, 21121776, 22967772, 25152019, 26880915, 27217270 | |
| PA451201 | quetiapine | Chemical | VariantAnnotation | associated | PD | 20504252 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 17632216, 17702092, 19142101, 19193342, 19997080, 20504252, 20680028, 22967772, 25152019, 26880915, 27217270 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | PD | 15635667, 15666332, 16633140, 17016522, 17632216, 17702092, 18718676, 19142101, 19193342, 19434072, 19636338, 19997080, 20504252, 20680028, 21121776, 21510767, 22967772, 24885933, 25152019, 26880915, 27217270 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36658216 | 2023 | Variation in serotonin 2C receptor linked with obesity and behaviour. | 0 |
| 37238670 | 2023 | Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. | 2 |
| 37768455 | 2023 | Association of Serotonin Receptor Gene Polymorphisms with Regulatory and Adaptive Capacities of Medical Students. | 0 |
| 36658216 | 2023 | Variation in serotonin 2C receptor linked with obesity and behaviour. | 0 |
| 37238670 | 2023 | Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma. | 2 |
| 37768455 | 2023 | Association of Serotonin Receptor Gene Polymorphisms with Regulatory and Adaptive Capacities of Medical Students. | 0 |
| 36536256 | 2022 | Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. | 10 |
| 36536256 | 2022 | Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. | 10 |
| 33683783 | 2021 | Effect of 5-HT2C receptor gene polymorphism (HTR2C-759C/T) on metabolic adverse effects in Thai psychiatric patients treated with risperidone. | 1 |
| 34367066 | 2021 | Central 5-HTR2C in the Control of Metabolic Homeostasis. | 6 |
| 34990340 | 2021 | Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population. | 0 |
| 33683783 | 2021 | Effect of 5-HT2C receptor gene polymorphism (HTR2C-759C/T) on metabolic adverse effects in Thai psychiatric patients treated with risperidone. | 1 |
| 34367066 | 2021 | Central 5-HTR2C in the Control of Metabolic Homeostasis. | 6 |
| 34990340 | 2021 | Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population. | 0 |
| 31187473 | 2020 | Serotonin system gene variants and regional brain volume differences in pediatric OCD. | 3 |
Citation
Dessen P
HTR2C (5-hydroxytryptamine receptor 2C)
Atlas Genet Cytogenet Oncol Haematol. 2016-01-01
Online version: http://atlasgeneticsoncology.org/gene/55615/htr2c-(5-hydroxytryptamine-receptor-2c)
