UGT1A4 (UDP glucuronosyltransferase family 1 member A4)

2015-03-01 Affiliation

Identity

HGNC

UGT1A4

LOCATION

2q37.1

LOCUSID

54657

ALIAS

GNT1,HUG-BR2,UDPGT,UDPGT

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 54657
MIM: 606429
HGNC: 12536
Ensembl: ENSG00000244474

Variants:

dbSNP: 54657
ClinVar: 54657
TCGA: ENSG00000244474
COSMIC: UGT1A4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000244474	ENST00000373409	P22310
ENSG00000244474	ENST00000450233	P22310

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pentose and glucuronate interconversions	KEGG	ko00040
Ascorbate and aldarate metabolism	KEGG	ko00053
Steroid hormone biosynthesis	KEGG	ko00140
Retinol metabolism	KEGG	ko00830
Porphyrin and chlorophyll metabolism	KEGG	ko00860
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Drug metabolism - other enzymes	KEGG	ko00983
Pentose and glucuronate interconversions	KEGG	hsa00040
Ascorbate and aldarate metabolism	KEGG	hsa00053
Steroid hormone biosynthesis	KEGG	hsa00140
Retinol metabolism	KEGG	hsa00830
Porphyrin and chlorophyll metabolism	KEGG	hsa00860
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Drug metabolism - other enzymes	KEGG	hsa00983
Metabolic pathways	KEGG	hsa01100
Glucuronate pathway (uronate pathway)	KEGG	M00014
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Glucuronate pathway (uronate pathway)	KEGG	hsa_M00014
Metabolism	REACTOME	R-HSA-1430728
Metabolism of porphyrins	REACTOME	R-HSA-189445
Heme degradation	REACTOME	R-HSA-189483
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glucuronidation	REACTOME	R-HSA-156588

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA165110775	SN-38	Chemical	Pathway	associated
PA165958521	febuxostat	Chemical	ClinicalAnnotation	associated		PD	27798726
PA166104276	ABT-751	Chemical	ClinicalAnnotation	associated	PK		23670235
PA166131338	tamoxifen-n-glucuronide	Chemical	MultilinkAnnotation	associated			27098059
PA166213001	clozapine 5-N-glucuronide	Chemical	VariantAnnotation	associated	PK		22565219
PA420	UGT1A1	Gene	VipGene	associated			15179404, 18004212, 18491077, 18518849, 19794410, 19997083, 8467709, 11434514
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	22047493, 27098059
PA444065	Epilepsy	Disease	ClinicalAnnotation	associated	PK	PD	23263737, 24820767, 26790665, 28763744, 29791014
PA444318	Gout	Disease	ClinicalAnnotation	associated		PD	27798726
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated	PK		23670235
PA445601	Osteosarcoma	Disease	ClinicalAnnotation	associated	PK		29791011
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD
PA448320	allopurinol	Chemical	ClinicalAnnotation	associated		PD	27798726
PA448432	anastrozole	Chemical	ClinicalAnnotation	associated	PK		23371966
PA450164	lamotrigine	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	22047493, 23263737, 24820767, 26790665, 29791014
PA450428	methotrexate	Chemical	ClinicalAnnotation	associated	PK		29791011
PA450496	midazolam	Chemical	Pathway	associated
PA450688	olanzapine	Chemical	VariantAnnotation	ambiguous	PK		21750471
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD
PA451581	tamoxifen	Chemical	ClinicalAnnotation, Pathway, VariantAnnotation	ambiguous	PK	PD	22047493, 23962908, 27098059
PA451627	testosterone	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	22047493
PA451846	valproic acid	Chemical	ClinicalAnnotation	associated	PK		28763744
PA451899	vitamin d and analogues	Chemical	Literature, MultilinkAnnotation	associated			24641623

References

Pubmed ID	Year	Title	Citations
36178169	2023	Hepatotoxicity with High-Dose Green Tea Extract: Effect of Catechol-O-Methyltransferase and Uridine 5'-Diphospho-glucuronosyltransferase 1A4 Genotypes.	0
37340142	2023	Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.	1
36178169	2023	Hepatotoxicity with High-Dose Green Tea Extract: Effect of Catechol-O-Methyltransferase and Uridine 5'-Diphospho-glucuronosyltransferase 1A4 Genotypes.	0
37340142	2023	Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.	1
34046917	2021	A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.	1
34046917	2021	A validation study of the UGT1A4 rs2011404 variant and the risk of anti-tuberculosis drug-induced hepatotoxicity in an Eastern Chinese Han population.	1
31797717	2020	Association of CYP2C19 and UGT1A4 polymorphisms with voriconazole-induced liver injury.	2
32070304	2020	The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine.	6
32456253	2020	Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.	3
31797717	2020	Association of CYP2C19 and UGT1A4 polymorphisms with voriconazole-induced liver injury.	2
32070304	2020	The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine.	6
32456253	2020	Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients' Population.	3
30630678	2019	The Effect of Polymorphism in UGT1A4 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Patients With Breast Cancer in China.	1
30630678	2019	The Effect of Polymorphism in UGT1A4 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Patients With Breast Cancer in China.	1
29395496	2018	UGT polymorphisms and lamotrigine clearance during pregnancy.	12

Citation

Dessen P

UGT1A4 (UDP glucuronosyltransferase family 1 member A4)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55625/ugt1a4-(udp-glucuronosyltransferase-family-1-member-a4)