NECTIN2 (nectin cell adhesion molecule 2)

2015-03-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
CD112,HVEB,PRR2,PVRL2,PVRR2
FUSION GENES

Other Information

Locus ID:

NCBI: 5819
MIM: 600798
HGNC: 9707
Ensembl: ENSG00000130202

Variants:

dbSNP: 5819
ClinVar: 5819
TCGA: ENSG00000130202
COSMIC: NECTIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130202ENST00000252483Q92692
ENSG00000130202ENST00000252485Q92692
ENSG00000130202ENST00000585601K7EK87
ENSG00000130202ENST00000591581K7EKE8
ENSG00000130202ENST00000592018K7ERL3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129130962003Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule.237
198154992009The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity.179
155361442005Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112).106
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
213837662012Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients.54
204103142010Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112.40
124386202002Mutations in the N-terminal domains of nectin-1 and nectin-2 reveal differences in requirements for entry of various alphaherpesviruses and for nectin-nectin interactions.21
229274152012Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion.19
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
168318682006Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process.17

Citation

Dessen P

NECTIN2 (nectin cell adhesion molecule 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55629/nectin2-(nectin-cell-adhesion-molecule-2)