Identity
HGNC
LOCATION
3q13.13
LOCUSID
ALIAS
B7-H5,B7-H7,B7H7,B7y
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 11148
MIM: 604371
HGNC: 4905
Ensembl: ENSG00000114455
Variants:
dbSNP: 11148
ClinVar: 11148
TCGA: ENSG00000114455
COSMIC: HHLA2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38321252 | 2024 | HHLA2 is more significantly associated with poor prognosis in TSCC than PD-L1. | 0 |
| 38578157 | 2024 | HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway. | 0 |
| 38762741 | 2024 | HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway. | 0 |
| 38321252 | 2024 | HHLA2 is more significantly associated with poor prognosis in TSCC than PD-L1. | 0 |
| 38578157 | 2024 | HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway. | 0 |
| 38762741 | 2024 | HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway. | 0 |
| 35761035 | 2023 | Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II Scores. | 0 |
| 35933091 | 2023 | KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy. | 14 |
| 36535461 | 2023 | Silencing tumor-intrinsic HHLA2 potentiates the anti-tumoral effect of paclitaxel on MG63 cells: Another side of immune checkpoint. | 4 |
| 36598731 | 2023 | Increased co-expression of stromal HHLA2 and fibroblast activation protein in upper tract urothelial carcinoma. | 2 |
| 36846109 | 2023 | Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease. | 3 |
| 36982953 | 2023 | Overexpression and Role of HHLA2, a Novel Immune Checkpoint, in Colorectal Cancer. | 6 |
| 37011487 | 2023 | HHLA2 immune-regulatory roles in cancer. | 5 |
| 37891555 | 2023 | Regulation of HHLA2 expression in kidney cancer and myeloid cells. | 2 |
| 35761035 | 2023 | Decrease of Membrane B7-H5 on CD14+ Cells in Severe Acute Pancreatitis Is Related to RANSON Scores and APACHE II Scores. | 0 |
Citation
Dessen P
HHLA2 (HERV-H LTR-associating 2)
Atlas Genet Cytogenet Oncol Haematol. 2015-03-01
Online version: http://atlasgeneticsoncology.org/gene/55630/hhla2-(herv-h-ltr-associating-2)
