Identity
HGNC
LOCATION
Xp11.21
LOCUSID
ALIAS
ALS15,CHAP1,DSK2,HRIHFB2157,N4BP4,PLIC2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 29978
MIM: 300264
HGNC: 12509
Ensembl: ENSG00000188021
Variants:
dbSNP: 29978
ClinVar: 29978
TCGA: ENSG00000188021
COSMIC: UBQLN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000188021 | ENST00000338222 | Q9UHD9 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38115557 | 2024 | Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia. | 1 |
| 38115557 | 2024 | Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia. | 1 |
| 36423739 | 2023 | UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding. | 1 |
| 36951542 | 2023 | UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS. | 7 |
| 37257946 | 2023 | Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways. | 1 |
| 36423739 | 2023 | UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding. | 1 |
| 36951542 | 2023 | UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS. | 7 |
| 37257946 | 2023 | Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways. | 1 |
| 34750982 | 2022 | Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1. | 9 |
| 35063704 | 2022 | Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis. | 2 |
| 35777956 | 2022 | Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. | 3 |
| 36232630 | 2022 | Damaged DNA Is an Early Event of Neurodegeneration in Induced Pluripotent Stem Cell-Derived Motoneurons with UBQLN2(P497H) Mutation. | 1 |
| 34750982 | 2022 | Amyotrophic lateral sclerosis (ALS) linked mutation in Ubiquilin 2 affects stress granule assembly via TIA-1. | 9 |
| 35063704 | 2022 | Towards a molecular understanding of the overlapping and distinct roles of UBQLN1 and UBQLN2 in lung cancer progression and metastasis. | 2 |
| 35777956 | 2022 | Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants. | 3 |
Citation
Dessen P
UBQLN2 (ubiquilin 2)
Atlas Genet Cytogenet Oncol Haematol. 2015-03-01
Online version: http://atlasgeneticsoncology.org/gene/55631/ubqln2-(ubiquilin-2)
