Identity
HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
IIAE1,UNC93,UNC93B,Unc-93B1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 81622
MIM: 608204
HGNC: 13481
Ensembl: ENSG00000110057
Variants:
dbSNP: 81622
ClinVar: 81622
TCGA: ENSG00000110057
COSMIC: UNC93B1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000110057 | ENST00000227471 | Q9H1C4 |
| ENSG00000110057 | ENST00000524455 | E9PR93 |
| ENSG00000110057 | ENST00000528423 | E9PNE5 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38207055 | 2024 | UNC93B1 variants underlie TLR7-dependent autoimmunity. | 5 |
| 38831104 | 2024 | Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus. | 1 |
| 38869500 | 2024 | Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus. | 0 |
| 38207055 | 2024 | UNC93B1 variants underlie TLR7-dependent autoimmunity. | 5 |
| 38831104 | 2024 | Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus. | 1 |
| 38869500 | 2024 | Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus. | 0 |
| 35577759 | 2022 | UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation. | 18 |
| 35577759 | 2022 | UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation. | 18 |
| 33432245 | 2021 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1. | 35 |
| 33627833 | 2021 | Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. | 4 |
| 33837956 | 2021 | UNC93B1 curbs cytosolic DNA signaling by promoting STING degradation. | 7 |
| 34223897 | 2021 | Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment. | 2 |
| 34440442 | 2021 | Variants Affecting the C-Terminal Tail of UNC93B1 Are Not a Common Risk Factor for Systemic Lupus Erythematosus. | 0 |
| 33432245 | 2021 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1. | 35 |
| 33627833 | 2021 | Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. | 4 |
Citation
Dessen P
UNC93B1 (unc-93 homolog B1, TLR signaling regulator)
Atlas Genet Cytogenet Oncol Haematol. 2015-03-01
Online version: http://atlasgeneticsoncology.org/gene/55645/unc93b1-(unc-93-homolog-b1-tlr-signaling-regulator)
