USP30 (ubiquitin specific peptidase 30)

2015-03-01  

Identity

HGNC
LOCATION
12q24.11
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 84749
MIM: 612492
HGNC: 20065
Ensembl: ENSG00000135093

Variants:

dbSNP: 84749
ClinVar: 84749
TCGA: ENSG00000135093
COSMIC: USP30

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135093ENST00000257548Q70CQ3
ENSG00000135093ENST00000257548A0A024RBM3
ENSG00000135093ENST00000377883S4R354
ENSG00000135093ENST00000392784B3KUS5
ENSG00000135093ENST00000470117S4R3D1
ENSG00000135093ENST00000536393F5H3L3
ENSG00000135093ENST00000536723F5H8D3
ENSG00000135093ENST00000539121F5GXG2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380407892024USP30 inhibition protects dopaminergic neurons.0
380407892024USP30 inhibition protects dopaminergic neurons.0
346945692022LncRNA USP30-AS1 promotes the survival of acute myeloid leukemia cells by cis-regulating USP30 and ANKRD13A.15
346945692022LncRNA USP30-AS1 promotes the survival of acute myeloid leukemia cells by cis-regulating USP30 and ANKRD13A.15
322219682021The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis.49
322219682021The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis.49
321426852020Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.83
324843302020Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues.4
326362172020USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.44
321426852020Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling.83
324843302020Probing the Active Site of Deubiquitinase USP30 with Noncanonical Tryptophan Analogues.4
326362172020USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.44
307004972019Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy.34
307004972019Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy.34
298957122018Dual role of USP30 in controlling basal pexophagy and mitophagy.68

Citation

Dessen P

USP30 (ubiquitin specific peptidase 30)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55652/usp30-(ubiquitin-specific-peptidase-30)