NECTIN3 (nectin cell adhesion molecule 3)

2015-03-01 Affiliation

Identity

HGNC

NECTIN3

LOCATION

3q13.13

LOCUSID

25945

ALIAS

CD113,CDW113,NECTIN-3,PPR3,PRR3,PVRL3,PVRR3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25945
MIM: 607147
HGNC: 17664
Ensembl: ENSG00000177707

Variants:

dbSNP: 25945
ClinVar: 25945
TCGA: ENSG00000177707
COSMIC: NECTIN3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000177707	ENST00000319792	Q9NQS3
ENSG00000177707	ENST00000461477	C9J795
ENSG00000177707	ENST00000481766	C9JMW3
ENSG00000177707	ENST00000485303	Q9NQS3
ENSG00000177707	ENST00000485506	H7C5G5
ENSG00000177707	ENST00000486596	H7C4L0
ENSG00000177707	ENST00000491525	C9IZE6
ENSG00000177707	ENST00000493615	Q9NQS3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Adherens junction	KEGG	ko04520
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Adherens junction	KEGG	hsa04520
Cell-Cell communication	REACTOME	R-HSA-1500931
Cell junction organization	REACTOME	R-HSA-446728
Cell-cell junction organization	REACTOME	R-HSA-421270
Adherens junctions interactions	REACTOME	R-HSA-418990
Nectin/Necl trans heterodimerization	REACTOME	R-HSA-420597

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
26038560	2015	Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.	48
20634891	2010	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	18
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
26602083	2015	Binding and entry of Clostridium difficile toxin B is mediated by multiple domains.	11
24386110	2013	The expression of the Nectin complex in human breast cancer and the role of Nectin-3 in the control of tight junctions during metastasis.	10
25690753	2015	Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis.	6
24116228	2013	Nectin-3 (CD113) interacts with Nectin-2 (CD112) to promote lymphocyte transendothelial migration.	4
22926846	2012	Eutopic endometrium and peritoneal, ovarian and colorectal endometriotic tissues express a different profile of nectin-1, -3, -4 and nectin-like molecule 2.	3
30469078	2019	Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells.	2

Citation

Dessen P

NECTIN3 (nectin cell adhesion molecule 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55656/nectin3-(nectin-cell-adhesion-molecule-3)