ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)

2015-03-01  

Identity

HGNC
ZDHHC5
LOCATION
11q12.1
LOCUSID
25921
ALIAS
DHHC5,ZNF375
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25921
MIM: 614586
HGNC: 18472
Ensembl: ENSG00000156599

Variants:

dbSNP: 25921
ClinVar: 25921
TCGA: ENSG00000156599
COSMIC: ZDHHC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156599ENST00000287169Q9C0B5
ENSG00000156599ENST00000287169A0A024R546
ENSG00000156599ENST00000527985Q9C0B5
ENSG00000156599ENST00000528177E9PMA5
ENSG00000156599ENST00000529447H0YEF4
ENSG00000156599ENST00000532842E9PJ97

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381776732024Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.0
382337912024ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.2
381776732024Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging.0
382337912024ZDHHC5-mediated S-palmitoylation of FAK promotes its membrane localization and epithelial-mesenchymal transition in glioma.2
380920002023ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.6
380920002023ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation.6
334157762021Regulation and function of the palmitoyl-acyltransferase ZDHHC5.9
349615242021The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.16
334157762021Regulation and function of the palmitoyl-acyltransferase ZDHHC5.9
349615242021The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.16
315479762020DHHC5 Mediates β-Adrenergic Signaling in Cardiomyocytes by Targeting Gα Proteins.15
327374052020Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.28
315479762020DHHC5 Mediates β-Adrenergic Signaling in Cardiomyocytes by Targeting Gα Proteins.15
327374052020Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase.28
306056772019DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.63

Citation

Dessen P

ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55657/zdhhc5-(zinc-finger-dhhc-type-palmitoyltransferase-5)