NECTIN1 (nectin cell adhesion molecule 1)

2015-03-01  

Identity

HGNC
NECTIN1
LOCATION
11q23.3
LOCUSID
5818
ALIAS
CD111,CLPED1,ED4,HIgR,HV1S,HVEC,OFC7,PRR,PRR1,PVRL1,PVRR,PVRR1,SK-12,nectin-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5818
MIM: 600644
HGNC: 9706
Ensembl: ENSG00000110400

Variants:

dbSNP: 5818
ClinVar: 5818
TCGA: ENSG00000110400
COSMIC: NECTIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110400ENST00000264025Q15223
ENSG00000110400ENST00000340882Q15223
ENSG00000110400ENST00000341398Q15223

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Adherens junctionKEGGko04520
Cell adhesion molecules (CAMs)KEGGhsa04514
Adherens junctionKEGGhsa04520
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Nectin/Necl trans heterodimerizationREACTOMER-HSA-420597

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384710412024Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function.0
384710412024Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function.0
372890552023Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions.1
372890552023Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions.1
362296742022Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion.4
362296742022Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion.4
343397912021A monoclonal antibody neutralizes pesudorabies virus by blocking gD binding to the receptor nectin-1.4
343397912021A monoclonal antibody neutralizes pesudorabies virus by blocking gD binding to the receptor nectin-1.4
322759692020Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice.69
332334032020Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells.5
322759692020Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice.69
332334032020Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells.5
307591432019Interaction between nectin-1 and the human natural killer cell receptor CD96.14
307603812019PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer.17
309173742019Nectin-1 Expression in Colorectal Cancer: Is There a Group of Patients with High Risk for Early Disease Recurrence?7

Citation

Dessen P

NECTIN1 (nectin cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55660/css/teaching-explorer/humanGenome