Identity
HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
CD111,CLPED1,ED4,HIgR,HV1S,HVEC,OFC7,PRR,PRR1,PVRL1,PVRR,PVRR1,SK-12,nectin-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5818
MIM: 600644
HGNC: 9706
Ensembl: ENSG00000110400
Variants:
dbSNP: 5818
ClinVar: 5818
TCGA: ENSG00000110400
COSMIC: NECTIN1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000110400 | ENST00000264025 | Q15223 |
| ENSG00000110400 | ENST00000340882 | Q15223 |
| ENSG00000110400 | ENST00000341398 | Q15223 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38471041 | 2024 | Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function. | 0 |
| 38471041 | 2024 | Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function. | 0 |
| 37289055 | 2023 | Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions. | 1 |
| 37289055 | 2023 | Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions. | 1 |
| 36229674 | 2022 | Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. | 4 |
| 36229674 | 2022 | Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion. | 4 |
| 34339791 | 2021 | A monoclonal antibody neutralizes pesudorabies virus by blocking gD binding to the receptor nectin-1. | 4 |
| 34339791 | 2021 | A monoclonal antibody neutralizes pesudorabies virus by blocking gD binding to the receptor nectin-1. | 4 |
| 32275969 | 2020 | Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice. | 69 |
| 33233403 | 2020 | Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells. | 5 |
| 32275969 | 2020 | Hepatocellular Carcinoma Cells Up-regulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-Cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice. | 69 |
| 33233403 | 2020 | Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells. | 5 |
| 30759143 | 2019 | Interaction between nectin-1 and the human natural killer cell receptor CD96. | 14 |
| 30760381 | 2019 | PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer. | 17 |
| 30917374 | 2019 | Nectin-1 Expression in Colorectal Cancer: Is There a Group of Patients with High Risk for Early Disease Recurrence? | 7 |
Citation
Dessen P
NECTIN1 (nectin cell adhesion molecule 1)
Atlas Genet Cytogenet Oncol Haematol. 2015-03-01
Online version: http://atlasgeneticsoncology.org/gene/55660/nectin1-(nectin-cell-adhesion-molecule-1)
