ACOD1 (aconitate decarboxylase 1)

2016-03-01  

Identity

HGNC
ACOD1
LOCATION
13q22.3
LOCUSID
730249
ALIAS
CAD,IRG1

Other Information

Locus ID:

NCBI: 730249
MIM: 615275
HGNC: 33904
Ensembl: ENSG00000102794

Variants:

dbSNP: 730249
ClinVar: 730249
TCGA: ENSG00000102794
COSMIC: ACOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102794ENST00000377462A6NK06
ENSG00000102794ENST00000449753H7C1Q4

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
385206892024Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides.0
385206892024Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides.0
364796172023Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.9
370962662023[Clinical features of 6 children with uridine-responsive developmental epileptic encephalopathy 50 caused by CAD gene variants].0
371159312023Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy.17
373652512023Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1.2
364796172023Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.9
370962662023[Clinical features of 6 children with uridine-responsive developmental epileptic encephalopathy 50 caused by CAD gene variants].0
371159312023Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy.17
373652512023Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1.2
360016822022Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis.13
360016822022Aconitate decarboxylase 1 is a mediator of polymicrobial sepsis.13
346074642021The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages.12
346074642021The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages.12
319973732020Immune-Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2-Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia-Reperfusion Injury.85

Citation

Dessen P

ACOD1 (aconitate decarboxylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55679/acod1-(aconitate-decarboxylase-1)