ANO6 (anoctamin 6)

2016-03-01  

Identity

HGNC
LOCATION
12q12
LOCUSID
ALIAS
BDPLT7,SCTS,TMEM16F
FUSION GENES

Other Information

Locus ID:

NCBI: 196527
MIM: 608663
HGNC: 25240
Ensembl: ENSG00000177119

Variants:

dbSNP: 196527
ClinVar: 196527
TCGA: ENSG00000177119
COSMIC: ANO6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177119ENST00000320560Q4KMQ2
ENSG00000177119ENST00000423947Q4KMQ2
ENSG00000177119ENST00000425752Q4KMQ2
ENSG00000177119ENST00000441606Q4KMQ2
ENSG00000177119ENST00000550630F8VX71

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380332862024Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis.2
389412742024TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.0
380332862024Deciphering and disrupting PIEZO1-TMEM16F interplay in hereditary xerocytosis.2
389412742024TMEM16F exacerbates tau pathology and mediates phosphatidylserine exposure in phospho-tau-burdened neurons.0
379607762023ANO6 is a reliable prognostic biomarker and correlates to macrophage polarization in breast cancer.0
379607762023ANO6 is a reliable prognostic biomarker and correlates to macrophage polarization in breast cancer.0
356703312022Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.6
356706672022Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.13
356703312022Supporting Cells of the Human Olfactory Epithelium Co-Express the Lipid Scramblase TMEM16F and ACE2 and May Cause Smell Loss by SARS-CoV-2 Spike-Induced Syncytia.6
356706672022Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion.13
333467882021Molecular underpinning of intracellular pH regulation on TMEM16F.15
336584342021Ca(2+) Sensitivity of Anoctamin 6/TMEM16F Is Regulated by the Putative Ca(2+)-Binding Reservoir at the N-Terminal Domain.4
337580602021TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation.7
343905152021Hyperuricemia enhances procoagulant activity of vascular endothelial cells through TMEM16F regulated phosphatidylserine exposure and microparticle release.10
344048082021TMEM16F and dynamins control expansive plasma membrane reservoirs.7

Citation

Dessen P

ANO6 (anoctamin 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55680/ano6-(anoctamin-6)