COL15A1 (collagen type XV alpha 1 chain)

2016-03-01 Affiliation

Identity

HGNC

COL15A1

LOCATION

9q22.33

LOCUSID

1306

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1306
MIM: 120325
HGNC: 2192
Ensembl: ENSG00000204291

Variants:

dbSNP: 1306
ClinVar: 1306
TCGA: ENSG00000204291
COSMIC: COL15A1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204291	ENST00000375001	P39059
ENSG00000204291	ENST00000610452	A0A087X0K0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Protein digestion and absorption	KEGG	ko04974
Protein digestion and absorption	KEGG	hsa04974
Extracellular matrix organization	REACTOME	R-HSA-1474244
Collagen formation	REACTOME	R-HSA-1474290
Collagen biosynthesis and modifying enzymes	REACTOME	R-HSA-1650814
Assembly of collagen fibrils and other multimeric structures	REACTOME	R-HSA-2022090
Degradation of the extracellular matrix	REACTOME	R-HSA-1474228
Collagen degradation	REACTOME	R-HSA-1442490
Collagen chain trimerization	REACTOME	R-HSA-8948216

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
25134534	2014	Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.	31
19834535	2009	Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.	27
11937714	2002	Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed in specialized basement membranes.	17
17355226	2007	The molecular structure of human tissue type XV presents a unique conformation among the collagens.	14
18171981	2007	Complete suppression of tumor formation by high levels of basement membrane collagen.	12
23621901	2013	Variations in COL15A1 and COL18A1 influence age of onset of primary open angle glaucoma.	12
20932905	2011	Crystal structure of the human collagen XV trimerization domain: a potent trimerizing unit common to multiplexin collagens.	8
26937007	2016	Slow Muscle Precursors Lay Down a Collagen XV Matrix Fingerprint to Guide Motor Axon Navigation.	7
19365806	2009	Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein.	5
22034088	2012	Extracellular calcium chronically induced human osteoblasts effects: specific modulation of osteocalcin and collagen type XV.	4

Citation

Dessen P

COL15A1 (collagen type XV alpha 1 chain)

Atlas Genet Cytogenet Oncol Haematol. 2016-03-01

Online version: http://atlasgeneticsoncology.org/gene/55683/col15a1-(collagen-type-xv-alpha-1-chain)