Identity
HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
APOLMT,MTRNAP,MTRPOL,h-mtRPOL
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5442
MIM: 601778
HGNC: 9200
Ensembl: ENSG00000099821
Variants:
dbSNP: 5442
ClinVar: 5442
TCGA: ENSG00000099821
COSMIC: POLRMT
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000099821 | ENST00000588649 | O00411 |
| ENSG00000099821 | ENST00000590336 | K7ESD1 |
| ENSG00000099821 | ENST00000590573 | K7EMH3 |
| ENSG00000099821 | ENST00000592863 | R4GN79 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38649537 | 2024 | SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. | 1 |
| 38649537 | 2024 | SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. | 1 |
| 34744028 | 2022 | TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. | 6 |
| 34744028 | 2022 | TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication. | 6 |
| 33602924 | 2021 | POLRMT mutations impair mitochondrial transcription causing neurological disease. | 18 |
| 34326320 | 2021 | The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth. | 21 |
| 33602924 | 2021 | POLRMT mutations impair mitochondrial transcription causing neurological disease. | 18 |
| 34326320 | 2021 | The requirement of mitochondrial RNA polymerase for non-small cell lung cancer cell growth. | 21 |
| 26403317 | 2016 | Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer. | 3 |
| 26586915 | 2016 | Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import. | 19 |
| 27436287 | 2016 | Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity. | 18 |
| 26403317 | 2016 | Association of DNA sequence variation in mitochondrial DNA polymerase with mitochondrial DNA synthesis and risk of oral cancer. | 3 |
| 26586915 | 2016 | Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import. | 19 |
| 27436287 | 2016 | Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity. | 18 |
| 26484416 | 2015 | Targeting mitochondrial RNA polymerase in acute myeloid leukemia. | 21 |
Citation
Dessen P
POLRMT (RNA polymerase mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2016-03-01
Online version: http://atlasgeneticsoncology.org/gene/55684/polrmt-(rna-polymerase-mitochondrial)
