Identity
HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
IL-1R8,TIR8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 59307
MIM: 605478
HGNC: 30575
Ensembl: ENSG00000185187
Variants:
dbSNP: 59307
ClinVar: 59307
TCGA: ENSG00000185187
COSMIC: SIGIRR
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36753974 | 2023 | IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC. | 5 |
| 36753974 | 2023 | IL-1R8: A molecular brake of anti-tumor and anti-viral activity of NK cells and ILC. | 5 |
| 34563711 | 2022 | SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut. | 13 |
| 34563711 | 2022 | SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut. | 13 |
| 33391457 | 2021 | IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. | 11 |
| 34036103 | 2021 | Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis. | 3 |
| 34083516 | 2021 | IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway. | 13 |
| 33391457 | 2021 | IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8. | 11 |
| 34036103 | 2021 | Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis. | 3 |
| 34083516 | 2021 | IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway. | 13 |
| 32210474 | 2020 | Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR. | 5 |
| 32945488 | 2020 | Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study. | 2 |
| 33123603 | 2020 | Negative Effects of SIGIRR on TRAF6 Ubiquitination in Acute Lung Injury In Vitro. | 2 |
| 33155227 | 2020 | MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr. | 1 |
| 32210474 | 2020 | Immune response against Chlamydia trachomatis via toll-like receptors is negatively regulated by SIGIRR. | 5 |
Citation
Dessen P
SIGIRR (single Ig and TIR domain containing)
Atlas Genet Cytogenet Oncol Haematol. 2016-03-01
Online version: http://atlasgeneticsoncology.org/gene/55686/sigirr-(single-ig-and-tir-domain-containing)
